Apoptosis in acute kidney injury

Navjotsingh Pabla, QingQing Wei, Zheng Dong

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Acute kidney injury (AKI), also called acute renal failure, is a major kidney disease associated with high mortality. Under the disease condition, renal tubular cells are reversibly or irreversibly injured, undergoing cell death in both forms of necrosis and apoptosis. Research during the last few years has established an important role for tubular cell apoptosis in ischemic as well as nephrotoxic AKI. The mechanisms underlying tubular cell apoptosis are being elucidated. Research in this area may lead to the development of novel therapeutic strategies for the prevention and treatment of AKI.

Original languageEnglish (US)
Title of host publicationEssentials of Apoptosis
Subtitle of host publicationA Guide for Basic and Clinical Research
PublisherHumana Press Inc.
Pages565-579
Number of pages15
ISBN (Electronic)9781603273817
ISBN (Print)9781603273800
DOIs
StatePublished - Jan 1 2009

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Keywords

  • Acute kidney injury
  • Apoptosis
  • Cisplatin
  • Ischemia
  • Nephrotoxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pabla, N., Wei, Q., & Dong, Z. (2009). Apoptosis in acute kidney injury. In Essentials of Apoptosis: A Guide for Basic and Clinical Research (pp. 565-579). Humana Press Inc.. https://doi.org/10.1007/978-1-60327-381-7_25