Abstract
Arachidonic acid (AA) and its metabolites (eicosanoids) represent powerful mediators, used by organisms to induce and suppress inflammation as a part of the innate response to disturbances. Several cell types participate in the synthesis and release of AA metabolites, while many cell types represent the targets for eicosanoid action. Endothelial cells (EC), forming a semi-permeable barrier between the interior space of blood vessels and underlying tissues, are of particular importance for the development of inflammation, since endothelium controls such diverse processes as vascular tone, homeostasis, adhesion of platelets and leukocytes to the vascular wall, and permeability of the vascular wall for cells and fluids. Proliferation and migration of endothelial cells contribute significantly to new vessel development (angiogenesis). This review discusses endothelial-specific synthesis and action of arachidonic acid derivatives with a particular focus on the mechanisms of signal transduction and associated intracellular protein targets.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-127 |
| Number of pages | 21 |
| Journal | Microvascular Research |
| Volume | 69 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 1 2005 |
| Externally published | Yes |
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Keywords
- Arachidonic acid
- Eicosanoids
- Endothelial cells
ASJC Scopus subject areas
- Biochemistry
- Cardiology and Cardiovascular Medicine
Cite this
Arachidonic acid cascade in endothelial pathobiology. / Bogatcheva, Natalia V.; Sergeeva, Marina G.; Dudek, Steven M.; Verin, Alexander Dmitriyevich.
In: Microvascular Research, Vol. 69, No. 3, 01.05.2005, p. 107-127.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Arachidonic acid cascade in endothelial pathobiology
AU - Bogatcheva, Natalia V.
AU - Sergeeva, Marina G.
AU - Dudek, Steven M.
AU - Verin, Alexander Dmitriyevich
PY - 2005/5/1
Y1 - 2005/5/1
N2 - Arachidonic acid (AA) and its metabolites (eicosanoids) represent powerful mediators, used by organisms to induce and suppress inflammation as a part of the innate response to disturbances. Several cell types participate in the synthesis and release of AA metabolites, while many cell types represent the targets for eicosanoid action. Endothelial cells (EC), forming a semi-permeable barrier between the interior space of blood vessels and underlying tissues, are of particular importance for the development of inflammation, since endothelium controls such diverse processes as vascular tone, homeostasis, adhesion of platelets and leukocytes to the vascular wall, and permeability of the vascular wall for cells and fluids. Proliferation and migration of endothelial cells contribute significantly to new vessel development (angiogenesis). This review discusses endothelial-specific synthesis and action of arachidonic acid derivatives with a particular focus on the mechanisms of signal transduction and associated intracellular protein targets.
AB - Arachidonic acid (AA) and its metabolites (eicosanoids) represent powerful mediators, used by organisms to induce and suppress inflammation as a part of the innate response to disturbances. Several cell types participate in the synthesis and release of AA metabolites, while many cell types represent the targets for eicosanoid action. Endothelial cells (EC), forming a semi-permeable barrier between the interior space of blood vessels and underlying tissues, are of particular importance for the development of inflammation, since endothelium controls such diverse processes as vascular tone, homeostasis, adhesion of platelets and leukocytes to the vascular wall, and permeability of the vascular wall for cells and fluids. Proliferation and migration of endothelial cells contribute significantly to new vessel development (angiogenesis). This review discusses endothelial-specific synthesis and action of arachidonic acid derivatives with a particular focus on the mechanisms of signal transduction and associated intracellular protein targets.
KW - Arachidonic acid
KW - Eicosanoids
KW - Endothelial cells
UR - http://www.scopus.com/inward/record.url?scp=19544368251&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19544368251&partnerID=8YFLogxK
U2 - 10.1016/j.mvr.2005.01.007
DO - 10.1016/j.mvr.2005.01.007
M3 - Review article
VL - 69
SP - 107
EP - 127
JO - Microvascular Research
JF - Microvascular Research
SN - 0026-2862
IS - 3
ER -