Are there cognitive and neurobehavioural correlates of hormonal neuroprotection for women after TBI?

Janet P. Niemeier, Jennifer H. Marwitz, William C. Walker, Lynne C. Davis, Tamara Bushnik, David L. Ripley, Jessica McKinney Ketchum

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study examined possible cognitive correlates of hormonal neuroprotection following traumatic brain injury (TBI) using archival neuropsychological findings for 1563 individuals undergoing acute TBI rehabilitation between 1989 and 2002. Presumed age of menopause was based on the STRAW (Stages of Reproductive Aging) staging system (Soules, 2005; Soules et al., 2001) and general linear model (GLM) analysis of performance on neuropsychological testing by participants across gender and age groups (25-34, 35-44, 45-54, and 55-64) was performed. Hypotheses were (1) women with TBI in the oldest age group would have lower scores on neuropsychological tests and functional outcome measures than women in the younger groups, and (2) men in the oldest age group would have higher scores than women of the same age group. Analyses revealed that oldest females had significantly worse Trails B and SDMT written and oral scores than the youngest females. In addition, oldest females had significantly better Trails B, Rey AVLT and SDMT written scores than the oldest males. Possible cohort exposure to hormone replacement therapy, unknown hormonal status at time of testing, and sample-specific injury characteristics may have contributed to these findings.

Original languageEnglish (US)
Pages (from-to)363-382
Number of pages20
JournalNeuropsychological Rehabilitation
Volume23
Issue number3
DOIs
StatePublished - Jun 1 2013

Fingerprint

Age Groups
Neuropsychological Tests
Hormone Replacement Therapy
Menopause
Brain Injuries
Linear Models
Rehabilitation
Outcome Assessment (Health Care)
Neuroprotection
Traumatic Brain Injury
Wounds and Injuries
Trails
Testing

Keywords

  • Hormonal neuroprotection
  • Neuropsychological outcome
  • Post-menopausal
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Rehabilitation
  • Arts and Humanities (miscellaneous)
  • Applied Psychology

Cite this

Niemeier, J. P., Marwitz, J. H., Walker, W. C., Davis, L. C., Bushnik, T., Ripley, D. L., & Ketchum, J. M. (2013). Are there cognitive and neurobehavioural correlates of hormonal neuroprotection for women after TBI? Neuropsychological Rehabilitation, 23(3), 363-382. https://doi.org/10.1080/09602011.2012.761944

Are there cognitive and neurobehavioural correlates of hormonal neuroprotection for women after TBI? / Niemeier, Janet P.; Marwitz, Jennifer H.; Walker, William C.; Davis, Lynne C.; Bushnik, Tamara; Ripley, David L.; Ketchum, Jessica McKinney.

In: Neuropsychological Rehabilitation, Vol. 23, No. 3, 01.06.2013, p. 363-382.

Research output: Contribution to journalArticle

Niemeier, JP, Marwitz, JH, Walker, WC, Davis, LC, Bushnik, T, Ripley, DL & Ketchum, JM 2013, 'Are there cognitive and neurobehavioural correlates of hormonal neuroprotection for women after TBI?', Neuropsychological Rehabilitation, vol. 23, no. 3, pp. 363-382. https://doi.org/10.1080/09602011.2012.761944
Niemeier, Janet P. ; Marwitz, Jennifer H. ; Walker, William C. ; Davis, Lynne C. ; Bushnik, Tamara ; Ripley, David L. ; Ketchum, Jessica McKinney. / Are there cognitive and neurobehavioural correlates of hormonal neuroprotection for women after TBI?. In: Neuropsychological Rehabilitation. 2013 ; Vol. 23, No. 3. pp. 363-382.
@article{e2403a831944411c9ae494476d00a4c5,
title = "Are there cognitive and neurobehavioural correlates of hormonal neuroprotection for women after TBI?",
abstract = "This study examined possible cognitive correlates of hormonal neuroprotection following traumatic brain injury (TBI) using archival neuropsychological findings for 1563 individuals undergoing acute TBI rehabilitation between 1989 and 2002. Presumed age of menopause was based on the STRAW (Stages of Reproductive Aging) staging system (Soules, 2005; Soules et al., 2001) and general linear model (GLM) analysis of performance on neuropsychological testing by participants across gender and age groups (25-34, 35-44, 45-54, and 55-64) was performed. Hypotheses were (1) women with TBI in the oldest age group would have lower scores on neuropsychological tests and functional outcome measures than women in the younger groups, and (2) men in the oldest age group would have higher scores than women of the same age group. Analyses revealed that oldest females had significantly worse Trails B and SDMT written and oral scores than the youngest females. In addition, oldest females had significantly better Trails B, Rey AVLT and SDMT written scores than the oldest males. Possible cohort exposure to hormone replacement therapy, unknown hormonal status at time of testing, and sample-specific injury characteristics may have contributed to these findings.",
keywords = "Hormonal neuroprotection, Neuropsychological outcome, Post-menopausal, Traumatic brain injury",
author = "Niemeier, {Janet P.} and Marwitz, {Jennifer H.} and Walker, {William C.} and Davis, {Lynne C.} and Tamara Bushnik and Ripley, {David L.} and Ketchum, {Jessica McKinney}",
year = "2013",
month = "6",
day = "1",
doi = "10.1080/09602011.2012.761944",
language = "English (US)",
volume = "23",
pages = "363--382",
journal = "Neuropsychological Rehabilitation",
issn = "0960-2011",
publisher = "Psychology Press Ltd",
number = "3",

}

TY - JOUR

T1 - Are there cognitive and neurobehavioural correlates of hormonal neuroprotection for women after TBI?

AU - Niemeier, Janet P.

AU - Marwitz, Jennifer H.

AU - Walker, William C.

AU - Davis, Lynne C.

AU - Bushnik, Tamara

AU - Ripley, David L.

AU - Ketchum, Jessica McKinney

PY - 2013/6/1

Y1 - 2013/6/1

N2 - This study examined possible cognitive correlates of hormonal neuroprotection following traumatic brain injury (TBI) using archival neuropsychological findings for 1563 individuals undergoing acute TBI rehabilitation between 1989 and 2002. Presumed age of menopause was based on the STRAW (Stages of Reproductive Aging) staging system (Soules, 2005; Soules et al., 2001) and general linear model (GLM) analysis of performance on neuropsychological testing by participants across gender and age groups (25-34, 35-44, 45-54, and 55-64) was performed. Hypotheses were (1) women with TBI in the oldest age group would have lower scores on neuropsychological tests and functional outcome measures than women in the younger groups, and (2) men in the oldest age group would have higher scores than women of the same age group. Analyses revealed that oldest females had significantly worse Trails B and SDMT written and oral scores than the youngest females. In addition, oldest females had significantly better Trails B, Rey AVLT and SDMT written scores than the oldest males. Possible cohort exposure to hormone replacement therapy, unknown hormonal status at time of testing, and sample-specific injury characteristics may have contributed to these findings.

AB - This study examined possible cognitive correlates of hormonal neuroprotection following traumatic brain injury (TBI) using archival neuropsychological findings for 1563 individuals undergoing acute TBI rehabilitation between 1989 and 2002. Presumed age of menopause was based on the STRAW (Stages of Reproductive Aging) staging system (Soules, 2005; Soules et al., 2001) and general linear model (GLM) analysis of performance on neuropsychological testing by participants across gender and age groups (25-34, 35-44, 45-54, and 55-64) was performed. Hypotheses were (1) women with TBI in the oldest age group would have lower scores on neuropsychological tests and functional outcome measures than women in the younger groups, and (2) men in the oldest age group would have higher scores than women of the same age group. Analyses revealed that oldest females had significantly worse Trails B and SDMT written and oral scores than the youngest females. In addition, oldest females had significantly better Trails B, Rey AVLT and SDMT written scores than the oldest males. Possible cohort exposure to hormone replacement therapy, unknown hormonal status at time of testing, and sample-specific injury characteristics may have contributed to these findings.

KW - Hormonal neuroprotection

KW - Neuropsychological outcome

KW - Post-menopausal

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=84878296065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878296065&partnerID=8YFLogxK

U2 - 10.1080/09602011.2012.761944

DO - 10.1080/09602011.2012.761944

M3 - Article

C2 - 23362827

AN - SCOPUS:84878296065

VL - 23

SP - 363

EP - 382

JO - Neuropsychological Rehabilitation

JF - Neuropsychological Rehabilitation

SN - 0960-2011

IS - 3

ER -