How do different actin structures assemble from a common monomer pool? Skruber et al. show that the monomer-binding protein PFN1 is required for Arp2/3 and Mena/VASP network assembly at the leading edge. Altering PFN1 concentration changes how these networks compete and collaborate, driving the formation of different leading-edge actin structures.
- leading edge
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)