Abstract
How do different actin structures assemble from a common monomer pool? Skruber et al. show that the monomer-binding protein PFN1 is required for Arp2/3 and Mena/VASP network assembly at the leading edge. Altering PFN1 concentration changes how these networks compete and collaborate, driving the formation of different leading-edge actin structures.
Original language | English (US) |
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Pages (from-to) | 2651-2664.e5 |
Journal | Current Biology |
Volume | 30 |
Issue number | 14 |
DOIs | |
State | Published - Jul 20 2020 |
Externally published | Yes |
Keywords
- Arp2/3
- Mena/VASP
- actin
- assembly
- filopodia
- lamellipodia
- leading edge
- monomer
- polymerization
- profilin
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences