Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge

Kristen Skruber, Peyton V. Warp, Rachael Shklyarov, James D. Thomas, Maurice S. Swanson, Jessica L. Henty-Ridilla, Tracy Ann Read, Eric A. Vitriol

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

How do different actin structures assemble from a common monomer pool? Skruber et al. show that the monomer-binding protein PFN1 is required for Arp2/3 and Mena/VASP network assembly at the leading edge. Altering PFN1 concentration changes how these networks compete and collaborate, driving the formation of different leading-edge actin structures.

Original languageEnglish (US)
Pages (from-to)2651-2664.e5
JournalCurrent Biology
Volume30
Issue number14
DOIs
StatePublished - Jul 20 2020
Externally publishedYes

Keywords

  • Arp2/3
  • Mena/VASP
  • actin
  • assembly
  • filopodia
  • lamellipodia
  • leading edge
  • monomer
  • polymerization
  • profilin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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