Association of adenovirus 36 infection with adiposity and inflammatory-related markers in children

P. K. Berger, N. K. Pollock, E. M. Laing, S. J. Warden, K. M. Hill Gallant, D. B. Hausman, R. A. Tripp, L. D. McCabe, G. P. McCabe, C. M. Weaver, M. Peacock, R. D. Lewis

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Abstract

Context: Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal. Copyright

Objective: Associations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9-13 years (50% female, 49% black).

Design: Fasting blood samples were measured for presence of Ad36-specific antibodies and TNF-α IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry.

Results: The overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-α and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P < .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-α, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 1.2- 4.0], 2.4 (95% CI 1.4-4.0), and 1.8 (95% CI 1.0 -3.3), respectively, for those in the highest TNF-α, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05).

Conclusions: In children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.

Original languageEnglish (US)
Pages (from-to)3240-3246
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number9
DOIs
StatePublished - Sep 2014

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Adenoviridae Infections
Adiposity
Adenoviridae
Fats
Interleukin-6
Chemokine CCL2
Biomarkers
Vascular Endothelial Growth Factor A
Inflammation
Animals
Blood
Tissue
Photon Absorptiometry
X rays
Antibodies
Fasting
Obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Association of adenovirus 36 infection with adiposity and inflammatory-related markers in children. / Berger, P. K.; Pollock, N. K.; Laing, E. M.; Warden, S. J.; Hill Gallant, K. M.; Hausman, D. B.; Tripp, R. A.; McCabe, L. D.; McCabe, G. P.; Weaver, C. M.; Peacock, M.; Lewis, R. D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 9, 09.2014, p. 3240-3246.

Research output: Contribution to journalArticle

Berger, PK, Pollock, NK, Laing, EM, Warden, SJ, Hill Gallant, KM, Hausman, DB, Tripp, RA, McCabe, LD, McCabe, GP, Weaver, CM, Peacock, M & Lewis, RD 2014, 'Association of adenovirus 36 infection with adiposity and inflammatory-related markers in children', Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 9, pp. 3240-3246. https://doi.org/10.1210/jc.2014-1780
Berger, P. K. ; Pollock, N. K. ; Laing, E. M. ; Warden, S. J. ; Hill Gallant, K. M. ; Hausman, D. B. ; Tripp, R. A. ; McCabe, L. D. ; McCabe, G. P. ; Weaver, C. M. ; Peacock, M. ; Lewis, R. D. / Association of adenovirus 36 infection with adiposity and inflammatory-related markers in children. In: Journal of Clinical Endocrinology and Metabolism. 2014 ; Vol. 99, No. 9. pp. 3240-3246.
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title = "Association of adenovirus 36 infection with adiposity and inflammatory-related markers in children",
abstract = "Context: Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal. CopyrightObjective: Associations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9-13 years (50{\%} female, 49{\%} black).Design: Fasting blood samples were measured for presence of Ad36-specific antibodies and TNF-α IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry.Results: The overall prevalence of Ad36 seropositivity [Ad36(+)] was 42{\%}. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-α and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P < .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-α, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95{\%} confidence interval (CI) 1.2- 4.0], 2.4 (95{\%} CI 1.4-4.0), and 1.8 (95{\%} CI 1.0 -3.3), respectively, for those in the highest TNF-α, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05).Conclusions: In children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.",
author = "Berger, {P. K.} and Pollock, {N. K.} and Laing, {E. M.} and Warden, {S. J.} and {Hill Gallant}, {K. M.} and Hausman, {D. B.} and Tripp, {R. A.} and McCabe, {L. D.} and McCabe, {G. P.} and Weaver, {C. M.} and M. Peacock and Lewis, {R. D.}",
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T1 - Association of adenovirus 36 infection with adiposity and inflammatory-related markers in children

AU - Berger, P. K.

AU - Pollock, N. K.

AU - Laing, E. M.

AU - Warden, S. J.

AU - Hill Gallant, K. M.

AU - Hausman, D. B.

AU - Tripp, R. A.

AU - McCabe, L. D.

AU - McCabe, G. P.

AU - Weaver, C. M.

AU - Peacock, M.

AU - Lewis, R. D.

PY - 2014/9

Y1 - 2014/9

N2 - Context: Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal. CopyrightObjective: Associations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9-13 years (50% female, 49% black).Design: Fasting blood samples were measured for presence of Ad36-specific antibodies and TNF-α IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry.Results: The overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-α and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P < .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-α, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 1.2- 4.0], 2.4 (95% CI 1.4-4.0), and 1.8 (95% CI 1.0 -3.3), respectively, for those in the highest TNF-α, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05).Conclusions: In children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.

AB - Context: Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal. CopyrightObjective: Associations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9-13 years (50% female, 49% black).Design: Fasting blood samples were measured for presence of Ad36-specific antibodies and TNF-α IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry.Results: The overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-α and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P < .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-α, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 1.2- 4.0], 2.4 (95% CI 1.4-4.0), and 1.8 (95% CI 1.0 -3.3), respectively, for those in the highest TNF-α, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05).Conclusions: In children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.

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