TY - JOUR
T1 - Association of adenovirus 36 infection with adiposity and inflammatory-related markers in children
AU - Berger, P. K.
AU - Pollock, N. K.
AU - Laing, E. M.
AU - Warden, S. J.
AU - Hill Gallant, K. M.
AU - Hausman, D. B.
AU - Tripp, R. A.
AU - McCabe, L. D.
AU - McCabe, G. P.
AU - Weaver, C. M.
AU - Peacock, M.
AU - Lewis, R. D.
N1 - Publisher Copyright:
© 2014 by the Endocrine Society.
PY - 2014/9
Y1 - 2014/9
N2 - Context: Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal.Objective: Associations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9-13 years (50% female, 49% black).Design: Fasting blood samples were measured for presence of Ad36-specific antibodies and TNF-α IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry.Results: The overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-α and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P < .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-α, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 1.2- 4.0], 2.4 (95% CI 1.4-4.0), and 1.8 (95% CI 1.0 -3.3), respectively, for those in the highest TNF-α, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05).Conclusions: In children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.
AB - Context: Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal.Objective: Associations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9-13 years (50% female, 49% black).Design: Fasting blood samples were measured for presence of Ad36-specific antibodies and TNF-α IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry.Results: The overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-α and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P < .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-α, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 1.2- 4.0], 2.4 (95% CI 1.4-4.0), and 1.8 (95% CI 1.0 -3.3), respectively, for those in the highest TNF-α, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05).Conclusions: In children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.
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U2 - 10.1210/jc.2014-1780
DO - 10.1210/jc.2014-1780
M3 - Article
C2 - 24926952
AN - SCOPUS:84907222574
SN - 0021-972X
VL - 99
SP - 3240
EP - 3246
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -