Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study

Laura D Carbone, Petra Bůžková, Howard A. Fink, John A. Robbins, Monique Bethel, Mark W Hamrick, William D Hill

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.

Original languageEnglish (US)
Pages (from-to)599-608
Number of pages10
JournalCalcified Tissue International
Volume100
Issue number6
DOIs
StatePublished - Jun 1 2017

Fingerprint

Hip Fractures
Body Composition
Pelvic Bones
Bone Density
Osteoblasts
Bone Marrow Cells
Health
Stem Cells
Hematopoietic Stem Cell Mobilization
Chemokine CXCL12
Bone and Bones
Osteocytes
Osteoclasts
Osteogenesis
Cell Movement
Cell Differentiation
Cell Survival
Homeostasis
Cytokines

Keywords

  • Aging
  • Body composition
  • Cytokines
  • DXA
  • Epidemiology
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults : The Cardiovascular Health Study. / Carbone, Laura D; Bůžková, Petra; Fink, Howard A.; Robbins, John A.; Bethel, Monique; Hamrick, Mark W; Hill, William D.

In: Calcified Tissue International, Vol. 100, No. 6, 01.06.2017, p. 599-608.

Research output: Contribution to journalArticle

Carbone, Laura D ; Bůžková, Petra ; Fink, Howard A. ; Robbins, John A. ; Bethel, Monique ; Hamrick, Mark W ; Hill, William D. / Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults : The Cardiovascular Health Study. In: Calcified Tissue International. 2017 ; Vol. 100, No. 6. pp. 599-608.
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