Astroglial and neuronal integrity during cortical spreading depolarization

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In the minutes, hours and even days following stroke or traumatic brain injury (TBI), cerebral gray matter undergoes recurring waves of depolarization that spread across neurons and astrocytes. Originating near the site of injury, these waves of spreading depolarization migrate through regions of compromised blood flow, consuming precious energy and expanding the initial site of infarct or TBI. The collapseof ion gradients is the hallmark of spreading depolarization. This causes rapid astroglial and neuronal swelling (i.e. cytotoxic edema) and dendritic beading with spine loss which represents acute damage to synaptic circuitry. Spreading depolarization has long been associated with migraine aura and it was recently recognized as a novel mechanism of injury in stroke and TBI patients. Despite testing of numerous neuroprotective agents in clinical trials no neuroprotective drugs have proven helpful. This can be partially attributed to the inadequate understanding of the dynamic cellular processes that promote brain damage during recurring waves of spreading depolarization. A surprisingly large therapeutic window exists to diminish the depolarizing and hemodynamic activity of spreading depolarization waves and thus reduce subsequent secondary brain injury. In this chapter, the impact of spreading depolarization waves on neuronal and astroglial cellular integrity is described.

Original languageEnglish (US)
Title of host publicationPathological Potential of Neuroglia: Possible New Targets for Medical Intervention
PublisherSpringer New York
Pages127-153
Number of pages27
Volume9781493909742
ISBN (Print)9781493909742, 1493909738, 9781493909735
DOIs
StatePublished - Mar 1 2014

Fingerprint

Neuroprotective Agents
Stroke
Migraine with Aura
Wounds and Injuries
Astrocytes
Brain Injuries
Edema
Spine
Hemodynamics
Clinical Trials
Ions
Neurons
Brain
Traumatic Brain Injury
Therapeutics
Gray Matter

Keywords

  • Astroglial
  • Astroglial swelling
  • Depolarization
  • Excitotoxicity
  • Ischemia
  • Neuronal swelling
  • Polyanions
  • Repolarization
  • TBI
  • Traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Kirov, S. A. (2014). Astroglial and neuronal integrity during cortical spreading depolarization. In Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention (Vol. 9781493909742, pp. 127-153). Springer New York. https://doi.org/10.1007/978-1-4939-0974-2-7

Astroglial and neuronal integrity during cortical spreading depolarization. / Kirov, Sergei A.

Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. Vol. 9781493909742 Springer New York, 2014. p. 127-153.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kirov, SA 2014, Astroglial and neuronal integrity during cortical spreading depolarization. in Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. vol. 9781493909742, Springer New York, pp. 127-153. https://doi.org/10.1007/978-1-4939-0974-2-7
Kirov SA. Astroglial and neuronal integrity during cortical spreading depolarization. In Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. Vol. 9781493909742. Springer New York. 2014. p. 127-153 https://doi.org/10.1007/978-1-4939-0974-2-7
Kirov, Sergei A. / Astroglial and neuronal integrity during cortical spreading depolarization. Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. Vol. 9781493909742 Springer New York, 2014. pp. 127-153
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