Atypical Intracranial Meningioma with Metastasis to C7 Vertebral Body

A Case Report

Ayobami L. Ward, Aida Risman, Sharmila Segar, Suash Sharma, John R Vender

Research output: Contribution to journalArticle

Abstract

Background: Extracranial metastasis, mainly a feature of World Health Organization (WHO) grade III meningiomas, is only rarely reported in grade II meningiomas. Case Description: We report a case of a 48-year-old man who was initially diagnosed in 2010 with an occipital convexity meningioma based on computed tomography scan/magnetic resonance imaging (MRI) and treated with surgical therapy and gamma knife. The first operation achieved a macroscopically complete resection. The tumor was histologically classified as an atypical meningioma. The patient had a recurrence in 2014 on the left tentorial leaflet as noted on postcontrast MRI. The patient was asymptomatic, without focal neurologic deficits. In 2016, the patient reported new-onset pain in the neck and left upper extremity. MRI indicated complete replacement of the C7 vertebral marrow, with a soft tissue component extending posteriorly into the epidural space that appeared to be flattening the thecal sac but without evidence of abnormal cord signal. Histopathology of resection confirmed atypical meningioma. Conclusions: This case represents a rare instance of intraosseous spine as the first site of metastasis of WHO grade II atypical meningioma and is the first reported case of extracranial metastasis of a meningioma to the C7 vertebral body.

Original languageEnglish (US)
Pages (from-to)593-598
Number of pages6
JournalWorld Neurosurgery
Volume122
DOIs
StatePublished - Feb 1 2019

Fingerprint

Meningioma
Neoplasm Metastasis
Magnetic Resonance Imaging
Epidural Space
Neck Pain
Neurologic Manifestations
Upper Extremity
Spine
Bone Marrow
Tomography
Recurrence
Neoplasms

Keywords

  • Atypical
  • Meningioma
  • Metastatic
  • Radiosurgery
  • Resection
  • Spine

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Atypical Intracranial Meningioma with Metastasis to C7 Vertebral Body : A Case Report. / Ward, Ayobami L.; Risman, Aida; Segar, Sharmila; Sharma, Suash; Vender, John R.

In: World Neurosurgery, Vol. 122, 01.02.2019, p. 593-598.

Research output: Contribution to journalArticle

@article{7b1e25828497434789823e324739751c,
title = "Atypical Intracranial Meningioma with Metastasis to C7 Vertebral Body: A Case Report",
abstract = "Background: Extracranial metastasis, mainly a feature of World Health Organization (WHO) grade III meningiomas, is only rarely reported in grade II meningiomas. Case Description: We report a case of a 48-year-old man who was initially diagnosed in 2010 with an occipital convexity meningioma based on computed tomography scan/magnetic resonance imaging (MRI) and treated with surgical therapy and gamma knife. The first operation achieved a macroscopically complete resection. The tumor was histologically classified as an atypical meningioma. The patient had a recurrence in 2014 on the left tentorial leaflet as noted on postcontrast MRI. The patient was asymptomatic, without focal neurologic deficits. In 2016, the patient reported new-onset pain in the neck and left upper extremity. MRI indicated complete replacement of the C7 vertebral marrow, with a soft tissue component extending posteriorly into the epidural space that appeared to be flattening the thecal sac but without evidence of abnormal cord signal. Histopathology of resection confirmed atypical meningioma. Conclusions: This case represents a rare instance of intraosseous spine as the first site of metastasis of WHO grade II atypical meningioma and is the first reported case of extracranial metastasis of a meningioma to the C7 vertebral body.",
keywords = "Atypical, Meningioma, Metastatic, Radiosurgery, Resection, Spine",
author = "Ward, {Ayobami L.} and Aida Risman and Sharmila Segar and Suash Sharma and Vender, {John R}",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.wneu.2018.11.067",
language = "English (US)",
volume = "122",
pages = "593--598",
journal = "World Neurosurgery",
issn = "1878-8750",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Atypical Intracranial Meningioma with Metastasis to C7 Vertebral Body

T2 - A Case Report

AU - Ward, Ayobami L.

AU - Risman, Aida

AU - Segar, Sharmila

AU - Sharma, Suash

AU - Vender, John R

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: Extracranial metastasis, mainly a feature of World Health Organization (WHO) grade III meningiomas, is only rarely reported in grade II meningiomas. Case Description: We report a case of a 48-year-old man who was initially diagnosed in 2010 with an occipital convexity meningioma based on computed tomography scan/magnetic resonance imaging (MRI) and treated with surgical therapy and gamma knife. The first operation achieved a macroscopically complete resection. The tumor was histologically classified as an atypical meningioma. The patient had a recurrence in 2014 on the left tentorial leaflet as noted on postcontrast MRI. The patient was asymptomatic, without focal neurologic deficits. In 2016, the patient reported new-onset pain in the neck and left upper extremity. MRI indicated complete replacement of the C7 vertebral marrow, with a soft tissue component extending posteriorly into the epidural space that appeared to be flattening the thecal sac but without evidence of abnormal cord signal. Histopathology of resection confirmed atypical meningioma. Conclusions: This case represents a rare instance of intraosseous spine as the first site of metastasis of WHO grade II atypical meningioma and is the first reported case of extracranial metastasis of a meningioma to the C7 vertebral body.

AB - Background: Extracranial metastasis, mainly a feature of World Health Organization (WHO) grade III meningiomas, is only rarely reported in grade II meningiomas. Case Description: We report a case of a 48-year-old man who was initially diagnosed in 2010 with an occipital convexity meningioma based on computed tomography scan/magnetic resonance imaging (MRI) and treated with surgical therapy and gamma knife. The first operation achieved a macroscopically complete resection. The tumor was histologically classified as an atypical meningioma. The patient had a recurrence in 2014 on the left tentorial leaflet as noted on postcontrast MRI. The patient was asymptomatic, without focal neurologic deficits. In 2016, the patient reported new-onset pain in the neck and left upper extremity. MRI indicated complete replacement of the C7 vertebral marrow, with a soft tissue component extending posteriorly into the epidural space that appeared to be flattening the thecal sac but without evidence of abnormal cord signal. Histopathology of resection confirmed atypical meningioma. Conclusions: This case represents a rare instance of intraosseous spine as the first site of metastasis of WHO grade II atypical meningioma and is the first reported case of extracranial metastasis of a meningioma to the C7 vertebral body.

KW - Atypical

KW - Meningioma

KW - Metastatic

KW - Radiosurgery

KW - Resection

KW - Spine

UR - http://www.scopus.com/inward/record.url?scp=85058472508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058472508&partnerID=8YFLogxK

U2 - 10.1016/j.wneu.2018.11.067

DO - 10.1016/j.wneu.2018.11.067

M3 - Article

VL - 122

SP - 593

EP - 598

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

ER -