Abstract
Background: The surgical placement of dental implants is governed primarily by the prosthetic design and secondarily by the morphology and quality of the alveolar bone. Implant placement may be difficult, if at all possible, due to alveolar ridge aberrations. In consequence, prosthetically dictated dental implant positioning often entails augmentation of the alveolar ridge and adjacent structures. The objective of this review is to discuss recent observations of the biologic potential, the clinical relevance, and the perspectives of the application of recombinant human bone morphogenetic protein-2 (rhBMP-2) technology for alveolar bone augmentation and dental implant fixation. Methods: Our studies use discriminating, critical-size, supraalveolar defects in dogs to evaluate the biologic potential of the rhBMP-2 technology. We also use clinical modeling, including peri-implantitis and alveolar ridge defects and the maxillary sinus in preparation for clinical indications, in dogs and inhuman primates. Results: The results suggest that rhBMP-2 has substantial potential to augment alveolar bone and support dental implant fixation and functional loading. Conclusion and Clinical Relevance: Inclusion of rhBMP-2 for alveolar bone augmentation and dental implant fixation will not only enhance the predictability of the existing clinical protocol but will also allow new approaches to these procedures.
| Original language | English (US) |
|---|---|
| Journal | Journal of Bone and Joint Surgery - Series A |
| Volume | 83 |
| Issue number | SUPPL. 1 II |
| State | Published - Apr 20 2001 |
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ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Surgery
Cite this
Augmentation of alveolar bone and dental implant osseointegration : Clinical implication of studies with rhBMP-2. A comprehensive review. / Wikesjö, U. M.; Sorensen, R. G.; Wozney, J. M.
In: Journal of Bone and Joint Surgery - Series A, Vol. 83, No. SUPPL. 1 II, 20.04.2001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Augmentation of alveolar bone and dental implant osseointegration
T2 - Clinical implication of studies with rhBMP-2. A comprehensive review
AU - Wikesjö, U. M.
AU - Sorensen, R. G.
AU - Wozney, J. M.
PY - 2001/4/20
Y1 - 2001/4/20
N2 - Background: The surgical placement of dental implants is governed primarily by the prosthetic design and secondarily by the morphology and quality of the alveolar bone. Implant placement may be difficult, if at all possible, due to alveolar ridge aberrations. In consequence, prosthetically dictated dental implant positioning often entails augmentation of the alveolar ridge and adjacent structures. The objective of this review is to discuss recent observations of the biologic potential, the clinical relevance, and the perspectives of the application of recombinant human bone morphogenetic protein-2 (rhBMP-2) technology for alveolar bone augmentation and dental implant fixation. Methods: Our studies use discriminating, critical-size, supraalveolar defects in dogs to evaluate the biologic potential of the rhBMP-2 technology. We also use clinical modeling, including peri-implantitis and alveolar ridge defects and the maxillary sinus in preparation for clinical indications, in dogs and inhuman primates. Results: The results suggest that rhBMP-2 has substantial potential to augment alveolar bone and support dental implant fixation and functional loading. Conclusion and Clinical Relevance: Inclusion of rhBMP-2 for alveolar bone augmentation and dental implant fixation will not only enhance the predictability of the existing clinical protocol but will also allow new approaches to these procedures.
AB - Background: The surgical placement of dental implants is governed primarily by the prosthetic design and secondarily by the morphology and quality of the alveolar bone. Implant placement may be difficult, if at all possible, due to alveolar ridge aberrations. In consequence, prosthetically dictated dental implant positioning often entails augmentation of the alveolar ridge and adjacent structures. The objective of this review is to discuss recent observations of the biologic potential, the clinical relevance, and the perspectives of the application of recombinant human bone morphogenetic protein-2 (rhBMP-2) technology for alveolar bone augmentation and dental implant fixation. Methods: Our studies use discriminating, critical-size, supraalveolar defects in dogs to evaluate the biologic potential of the rhBMP-2 technology. We also use clinical modeling, including peri-implantitis and alveolar ridge defects and the maxillary sinus in preparation for clinical indications, in dogs and inhuman primates. Results: The results suggest that rhBMP-2 has substantial potential to augment alveolar bone and support dental implant fixation and functional loading. Conclusion and Clinical Relevance: Inclusion of rhBMP-2 for alveolar bone augmentation and dental implant fixation will not only enhance the predictability of the existing clinical protocol but will also allow new approaches to these procedures.
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M3 - Article
C2 - 11314791
AN - SCOPUS:0038792833
VL - 83
JO - Journal of Bone and Joint Surgery - Series A
JF - Journal of Bone and Joint Surgery - Series A
SN - 0021-9355
IS - SUPPL. 1 II
ER -