Augmentation of alveolar bone and dental implant osseointegration: Clinical implication of studies with rhBMP-2. A comprehensive review

U. M. Wikesjö, R. G. Sorensen, J. M. Wozney

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: The surgical placement of dental implants is governed primarily by the prosthetic design and secondarily by the morphology and quality of the alveolar bone. Implant placement may be difficult, if at all possible, due to alveolar ridge aberrations. In consequence, prosthetically dictated dental implant positioning often entails augmentation of the alveolar ridge and adjacent structures. The objective of this review is to discuss recent observations of the biologic potential, the clinical relevance, and the perspectives of the application of recombinant human bone morphogenetic protein-2 (rhBMP-2) technology for alveolar bone augmentation and dental implant fixation. Methods: Our studies use discriminating, critical-size, supraalveolar defects in dogs to evaluate the biologic potential of the rhBMP-2 technology. We also use clinical modeling, including peri-implantitis and alveolar ridge defects and the maxillary sinus in preparation for clinical indications, in dogs and inhuman primates. Results: The results suggest that rhBMP-2 has substantial potential to augment alveolar bone and support dental implant fixation and functional loading. Conclusion and Clinical Relevance: Inclusion of rhBMP-2 for alveolar bone augmentation and dental implant fixation will not only enhance the predictability of the existing clinical protocol but will also allow new approaches to these procedures.

Original languageEnglish (US)
JournalJournal of Bone and Joint Surgery - Series A
Volume83
Issue numberSUPPL. 1 II
StatePublished - Apr 20 2001

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Osseointegration
Dental Implants
Bone and Bones
Alveolar Process
Alveolar Ridge Augmentation
Peri-Implantitis
Dogs
Technology
Maxillary Sinus
Clinical Protocols
Primates
Clinical Studies
recombinant human bone morphogenetic protein-2

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

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Augmentation of alveolar bone and dental implant osseointegration : Clinical implication of studies with rhBMP-2. A comprehensive review. / Wikesjö, U. M.; Sorensen, R. G.; Wozney, J. M.

In: Journal of Bone and Joint Surgery - Series A, Vol. 83, No. SUPPL. 1 II, 20.04.2001.

Research output: Contribution to journalArticle

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