Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats

David W Stepp, Jefferson C. Frisbee

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

This study examined skeletal muscle microvessel reactivity to constrictor stimuli in obese (OZR) versus lean Zucker rats (LZR). Gracilis arteries from both rat groups were isolated, cannulated with glass micropipettes, and viewed via television microscopy. Changes in vessel diameter were measured with a video micrometer. Arterial constriction to norepinephrine was elevated in OZR versus LZR, although vasoconstrictor reactivity to endothelin and angiotensin II was unaltered. Differences in reactivity between vessels of LZR and OZR were not explained by the loss of either endothelial nitric oxide synthase or β-adrenergic receptor function. Reactivity of in situ cremasteric arterioles of OZR to norepinephrine was elevated versus LZR. Treatment with prazosin increased the diameter of in vivo gracilis arteries of OZR to levels determined in LZR and also normalized blood pressure in OZR. These results suggest that the constrictor reactivity of skeletal muscle microvessels in OZR is heightened in response to α-adrenergic stimuli and that development of diabetes in OZR may be associated with impaired skeletal muscle perfusion and hypertension due to microvessel hyperreactivity in response to sympathetic stimulation.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume282
Issue number3 51-3
StatePublished - Jun 29 2002

Fingerprint

Zucker Rats
Vasoconstriction
Adrenergic Agents
Microvessels
Skeletal Muscle
Norepinephrine
Arteries
Nitric Oxide Synthase Type III
Prazosin
Endothelins
Television
Arterioles
Vasoconstrictor Agents
Constriction
Angiotensin II
Adrenergic Receptors
Glass
Microscopy
Perfusion
Blood Pressure

Keywords

  • Hypertension
  • Norepinephine
  • Skeletal muscle microcirculation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats. / Stepp, David W; Frisbee, Jefferson C.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 282, No. 3 51-3, 29.06.2002.

Research output: Contribution to journalArticle

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