Autoimmune comorbidities are associated with brain injury in multiple sclerosis

R. Zivadinov, B. Raj, M. Ramanathan, B. Teter, J. Durfee, M. G. Dwyer, N. Bergsland, C. Kolb, D. Hojnacki, R. H. Benedict, B. Weinstock-Guttman

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: The effect of comorbidities on disease severity in MS has not been extensively characterized. We determined the association of comorbidities with MR imaging disease severity outcomes in MS. MATERIALS AND METHODS: Demographic and clinical history of 9 autoimmune comorbidities confirmed by retrospective chart review and quantitative MR imaging data were obtained in 815 patients with MS. The patients were categorized on the basis of the presence/ absence of total and specific comorbidities. We analyzed the MR imaging findings, adjusting for key covariates and correcting for multiple comparisons. RESULTS: Two hundred forty-one (29.6%) study subjects presented with comorbidities. Thyroid disease had the highest frequency (n = 97, 11.9%), followed by asthma (n = 41, 5%), type 2 diabetes mellitus (n = 40, 4.9%), psoriasis (n = 33, 4%), and rheumatoid arthritis (n = 22, 2.7%). Patients with MS with comorbidities showed decreased whole-brain and cortical volumes (P < .001), gray matter volume and magnetization transfer ratio of normal-appearing brain tissue (P<.01), and magnetization transfer ratio of gray matter (P<.05). Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities were associated with decreased whole-brain, cortical, and gray matter volumes (P < .05). Psoriasis was associated with a decreased magnetization transfer ratio of normal-appearing brain tissue (P < .05), while type 2 diabetes mellitus was associated with increased mean diffusivity (P < .01). CONCLUSIONS: The presence of comorbidities in patients with MS is associated with brain injury on MR imaging. Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities were associated with more severe nonconventional MR imaging outcomes.

Original languageEnglish (US)
Pages (from-to)1010-1016
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume37
Issue number6
DOIs
StatePublished - Jun 2016

Fingerprint

Brain Injuries
Multiple Sclerosis
Comorbidity
Psoriasis
Type 2 Diabetes Mellitus
Thyroid Diseases
Brain
Rheumatoid Arthritis
Asthma
Demography
Gray Matter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Zivadinov, R., Raj, B., Ramanathan, M., Teter, B., Durfee, J., Dwyer, M. G., ... Weinstock-Guttman, B. (2016). Autoimmune comorbidities are associated with brain injury in multiple sclerosis. American Journal of Neuroradiology, 37(6), 1010-1016. https://doi.org/10.3174/ajnr.A4681

Autoimmune comorbidities are associated with brain injury in multiple sclerosis. / Zivadinov, R.; Raj, B.; Ramanathan, M.; Teter, B.; Durfee, J.; Dwyer, M. G.; Bergsland, N.; Kolb, C.; Hojnacki, D.; Benedict, R. H.; Weinstock-Guttman, B.

In: American Journal of Neuroradiology, Vol. 37, No. 6, 06.2016, p. 1010-1016.

Research output: Contribution to journalArticle

Zivadinov, R, Raj, B, Ramanathan, M, Teter, B, Durfee, J, Dwyer, MG, Bergsland, N, Kolb, C, Hojnacki, D, Benedict, RH & Weinstock-Guttman, B 2016, 'Autoimmune comorbidities are associated with brain injury in multiple sclerosis', American Journal of Neuroradiology, vol. 37, no. 6, pp. 1010-1016. https://doi.org/10.3174/ajnr.A4681
Zivadinov, R. ; Raj, B. ; Ramanathan, M. ; Teter, B. ; Durfee, J. ; Dwyer, M. G. ; Bergsland, N. ; Kolb, C. ; Hojnacki, D. ; Benedict, R. H. ; Weinstock-Guttman, B. / Autoimmune comorbidities are associated with brain injury in multiple sclerosis. In: American Journal of Neuroradiology. 2016 ; Vol. 37, No. 6. pp. 1010-1016.
@article{8f3f68bd9db944bc83d53e60f333d9ee,
title = "Autoimmune comorbidities are associated with brain injury in multiple sclerosis",
abstract = "BACKGROUND AND PURPOSE: The effect of comorbidities on disease severity in MS has not been extensively characterized. We determined the association of comorbidities with MR imaging disease severity outcomes in MS. MATERIALS AND METHODS: Demographic and clinical history of 9 autoimmune comorbidities confirmed by retrospective chart review and quantitative MR imaging data were obtained in 815 patients with MS. The patients were categorized on the basis of the presence/ absence of total and specific comorbidities. We analyzed the MR imaging findings, adjusting for key covariates and correcting for multiple comparisons. RESULTS: Two hundred forty-one (29.6{\%}) study subjects presented with comorbidities. Thyroid disease had the highest frequency (n = 97, 11.9{\%}), followed by asthma (n = 41, 5{\%}), type 2 diabetes mellitus (n = 40, 4.9{\%}), psoriasis (n = 33, 4{\%}), and rheumatoid arthritis (n = 22, 2.7{\%}). Patients with MS with comorbidities showed decreased whole-brain and cortical volumes (P < .001), gray matter volume and magnetization transfer ratio of normal-appearing brain tissue (P<.01), and magnetization transfer ratio of gray matter (P<.05). Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities were associated with decreased whole-brain, cortical, and gray matter volumes (P < .05). Psoriasis was associated with a decreased magnetization transfer ratio of normal-appearing brain tissue (P < .05), while type 2 diabetes mellitus was associated with increased mean diffusivity (P < .01). CONCLUSIONS: The presence of comorbidities in patients with MS is associated with brain injury on MR imaging. Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities were associated with more severe nonconventional MR imaging outcomes.",
author = "R. Zivadinov and B. Raj and M. Ramanathan and B. Teter and J. Durfee and Dwyer, {M. G.} and N. Bergsland and C. Kolb and D. Hojnacki and Benedict, {R. H.} and B. Weinstock-Guttman",
year = "2016",
month = "6",
doi = "10.3174/ajnr.A4681",
language = "English (US)",
volume = "37",
pages = "1010--1016",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "6",

}

TY - JOUR

T1 - Autoimmune comorbidities are associated with brain injury in multiple sclerosis

AU - Zivadinov, R.

AU - Raj, B.

AU - Ramanathan, M.

AU - Teter, B.

AU - Durfee, J.

AU - Dwyer, M. G.

AU - Bergsland, N.

AU - Kolb, C.

AU - Hojnacki, D.

AU - Benedict, R. H.

AU - Weinstock-Guttman, B.

PY - 2016/6

Y1 - 2016/6

N2 - BACKGROUND AND PURPOSE: The effect of comorbidities on disease severity in MS has not been extensively characterized. We determined the association of comorbidities with MR imaging disease severity outcomes in MS. MATERIALS AND METHODS: Demographic and clinical history of 9 autoimmune comorbidities confirmed by retrospective chart review and quantitative MR imaging data were obtained in 815 patients with MS. The patients were categorized on the basis of the presence/ absence of total and specific comorbidities. We analyzed the MR imaging findings, adjusting for key covariates and correcting for multiple comparisons. RESULTS: Two hundred forty-one (29.6%) study subjects presented with comorbidities. Thyroid disease had the highest frequency (n = 97, 11.9%), followed by asthma (n = 41, 5%), type 2 diabetes mellitus (n = 40, 4.9%), psoriasis (n = 33, 4%), and rheumatoid arthritis (n = 22, 2.7%). Patients with MS with comorbidities showed decreased whole-brain and cortical volumes (P < .001), gray matter volume and magnetization transfer ratio of normal-appearing brain tissue (P<.01), and magnetization transfer ratio of gray matter (P<.05). Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities were associated with decreased whole-brain, cortical, and gray matter volumes (P < .05). Psoriasis was associated with a decreased magnetization transfer ratio of normal-appearing brain tissue (P < .05), while type 2 diabetes mellitus was associated with increased mean diffusivity (P < .01). CONCLUSIONS: The presence of comorbidities in patients with MS is associated with brain injury on MR imaging. Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities were associated with more severe nonconventional MR imaging outcomes.

AB - BACKGROUND AND PURPOSE: The effect of comorbidities on disease severity in MS has not been extensively characterized. We determined the association of comorbidities with MR imaging disease severity outcomes in MS. MATERIALS AND METHODS: Demographic and clinical history of 9 autoimmune comorbidities confirmed by retrospective chart review and quantitative MR imaging data were obtained in 815 patients with MS. The patients were categorized on the basis of the presence/ absence of total and specific comorbidities. We analyzed the MR imaging findings, adjusting for key covariates and correcting for multiple comparisons. RESULTS: Two hundred forty-one (29.6%) study subjects presented with comorbidities. Thyroid disease had the highest frequency (n = 97, 11.9%), followed by asthma (n = 41, 5%), type 2 diabetes mellitus (n = 40, 4.9%), psoriasis (n = 33, 4%), and rheumatoid arthritis (n = 22, 2.7%). Patients with MS with comorbidities showed decreased whole-brain and cortical volumes (P < .001), gray matter volume and magnetization transfer ratio of normal-appearing brain tissue (P<.01), and magnetization transfer ratio of gray matter (P<.05). Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities were associated with decreased whole-brain, cortical, and gray matter volumes (P < .05). Psoriasis was associated with a decreased magnetization transfer ratio of normal-appearing brain tissue (P < .05), while type 2 diabetes mellitus was associated with increased mean diffusivity (P < .01). CONCLUSIONS: The presence of comorbidities in patients with MS is associated with brain injury on MR imaging. Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities were associated with more severe nonconventional MR imaging outcomes.

UR - http://www.scopus.com/inward/record.url?scp=84974539692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974539692&partnerID=8YFLogxK

U2 - 10.3174/ajnr.A4681

DO - 10.3174/ajnr.A4681

M3 - Article

C2 - 26892983

AN - SCOPUS:84974539692

VL - 37

SP - 1010

EP - 1016

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 6

ER -