Autoimmune thrombocytopenia following autologous hematopoietic cell transplantation: Review of literature and treatment options

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Abstract

Autoimmune thrombocytopenia after high-dose chemotherapy and autologous bone marrow/peripheral blood stem cell transplantation occurs infrequently and only six cases meeting the criteria have been reported in the literature. All six of these patients had either acute myelogenous leukemia (AML) or lymphoblastic lymphoma (LBL). Immune thrombocytopenia following autologous transplantation in solid tumors has not been reported. We report the first case of autoimmune thrombocytopenia after high-dose chemotherapy and peripheral blood stem cell transplantation in a patient with breast cancer. A review of the literature has been conducted and treatment options are discussed. In two patients the condition resolved with treatment and in a third patient it improved. Immune-mediated thrombocytopenia in the post-transplant period is one of the causes of a low platelet count. It should be recognized promptly and treated.

Original languageEnglish (US)
Pages (from-to)925-927
Number of pages3
JournalBone Marrow Transplantation
Volume26
Issue number8
DOIs
StatePublished - Jan 1 2000

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Idiopathic Thrombocytopenic Purpura
Cell Transplantation
Peripheral Blood Stem Cell Transplantation
Drug Therapy
Autologous Transplantation
Therapeutics
Platelet Count
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Bone Marrow
Breast Neoplasms
Transplants
Neoplasms

Keywords

  • Autoimmune thrombocytopenia
  • Autologous stem cell transplantation
  • Breast cancer
  • ITP

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

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abstract = "Autoimmune thrombocytopenia after high-dose chemotherapy and autologous bone marrow/peripheral blood stem cell transplantation occurs infrequently and only six cases meeting the criteria have been reported in the literature. All six of these patients had either acute myelogenous leukemia (AML) or lymphoblastic lymphoma (LBL). Immune thrombocytopenia following autologous transplantation in solid tumors has not been reported. We report the first case of autoimmune thrombocytopenia after high-dose chemotherapy and peripheral blood stem cell transplantation in a patient with breast cancer. A review of the literature has been conducted and treatment options are discussed. In two patients the condition resolved with treatment and in a third patient it improved. Immune-mediated thrombocytopenia in the post-transplant period is one of the causes of a low platelet count. It should be recognized promptly and treated.",
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