Autophagy and Tubular Cell Death in the Kidney

Andrea Havasi, Zheng Dong

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Many common renal insults such as ischemia and toxic injury primarily target the tubular epithelial cells, especially the highly metabolically active proximal tubular segment. Tubular epithelial cells are particularly dependent on autophagy to maintain homeostasis and respond to stressors. The pattern of autophagy in the kidney has a unique spatial and chronologic signature. Recent evidence has shown that there is complex cross-talk between autophagy and various cell death pathways. This review specifically discusses the interplay between autophagy and cell death in the renal tubular epithelia. It is imperative to review this topic because recent discoveries have improved our mechanistic understanding of the autophagic process and have highlighted its broad clinical applications, making autophagy a major target for drug development.

Original languageEnglish (US)
Pages (from-to)174-188
Number of pages15
JournalSeminars in Nephrology
Volume36
Issue number3
DOIs
StatePublished - May 1 2016

Keywords

  • apoptosis
  • autophagy
  • cell death
  • renal tubule

ASJC Scopus subject areas

  • Nephrology

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