Autoradiographic studies of the mouse Fallopian tube

Lawrence D Devoe, Uwe E. Freese, Georgia Paulos

Research output: Contribution to journalArticle

Abstract

Cyclic histologic changes in the mouse Fallopian tube corresponding to a specific changing pattern of 3H-thymidine uptake into tubal epithelium suggest a direct correlation between the pattern of nuclear labeling and the cycle-dependent alterations in hormone titers. Human chorionic gonadotropin (HCG)-treated animals showed a peak uptake in reserve cells comparable to that of late proestrus/early estrus. Estradiol-treated animals showed an uptake pattern into secretory cells comparable to the pattern seen in late estrus/metestrus-1. Progesterone-treated animals showed a return to predominantly reserve cell uptake similar to that of the late cycle, metestrus-2/diestrus. These cyclic changes of uptake of 3H-thymidine are interpreted as a growth-maturation-function cycle designed to sustain the egg or zygote in the tube and to replenish the tubal epithelium at the end of a cycle or pregnancy. The intercalary cells are recognized as end-stage elements of predominantly degranulated secretory cells.

Original languageEnglish (US)
Pages (from-to)490-496
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume117
Issue number4
DOIs
StatePublished - Oct 15 1973

Fingerprint

Fallopian Tubes
Metestrus
Estrus
Thymidine
Epithelium
Diestrus
Proestrus
Zygote
Chorionic Gonadotropin
Progesterone
Ovum
Estradiol
Hormones
Pregnancy
Growth

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Autoradiographic studies of the mouse Fallopian tube. / Devoe, Lawrence D; Freese, Uwe E.; Paulos, Georgia.

In: American Journal of Obstetrics and Gynecology, Vol. 117, No. 4, 15.10.1973, p. 490-496.

Research output: Contribution to journalArticle

Devoe, Lawrence D ; Freese, Uwe E. ; Paulos, Georgia. / Autoradiographic studies of the mouse Fallopian tube. In: American Journal of Obstetrics and Gynecology. 1973 ; Vol. 117, No. 4. pp. 490-496.
@article{00ae18d90b4645fe82dc8766e849c1a6,
title = "Autoradiographic studies of the mouse Fallopian tube",
abstract = "Cyclic histologic changes in the mouse Fallopian tube corresponding to a specific changing pattern of 3H-thymidine uptake into tubal epithelium suggest a direct correlation between the pattern of nuclear labeling and the cycle-dependent alterations in hormone titers. Human chorionic gonadotropin (HCG)-treated animals showed a peak uptake in reserve cells comparable to that of late proestrus/early estrus. Estradiol-treated animals showed an uptake pattern into secretory cells comparable to the pattern seen in late estrus/metestrus-1. Progesterone-treated animals showed a return to predominantly reserve cell uptake similar to that of the late cycle, metestrus-2/diestrus. These cyclic changes of uptake of 3H-thymidine are interpreted as a growth-maturation-function cycle designed to sustain the egg or zygote in the tube and to replenish the tubal epithelium at the end of a cycle or pregnancy. The intercalary cells are recognized as end-stage elements of predominantly degranulated secretory cells.",
author = "Devoe, {Lawrence D} and Freese, {Uwe E.} and Georgia Paulos",
year = "1973",
month = "10",
day = "15",
doi = "10.1016/0002-9378(73)90110-5",
language = "English (US)",
volume = "117",
pages = "490--496",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Autoradiographic studies of the mouse Fallopian tube

AU - Devoe, Lawrence D

AU - Freese, Uwe E.

AU - Paulos, Georgia

PY - 1973/10/15

Y1 - 1973/10/15

N2 - Cyclic histologic changes in the mouse Fallopian tube corresponding to a specific changing pattern of 3H-thymidine uptake into tubal epithelium suggest a direct correlation between the pattern of nuclear labeling and the cycle-dependent alterations in hormone titers. Human chorionic gonadotropin (HCG)-treated animals showed a peak uptake in reserve cells comparable to that of late proestrus/early estrus. Estradiol-treated animals showed an uptake pattern into secretory cells comparable to the pattern seen in late estrus/metestrus-1. Progesterone-treated animals showed a return to predominantly reserve cell uptake similar to that of the late cycle, metestrus-2/diestrus. These cyclic changes of uptake of 3H-thymidine are interpreted as a growth-maturation-function cycle designed to sustain the egg or zygote in the tube and to replenish the tubal epithelium at the end of a cycle or pregnancy. The intercalary cells are recognized as end-stage elements of predominantly degranulated secretory cells.

AB - Cyclic histologic changes in the mouse Fallopian tube corresponding to a specific changing pattern of 3H-thymidine uptake into tubal epithelium suggest a direct correlation between the pattern of nuclear labeling and the cycle-dependent alterations in hormone titers. Human chorionic gonadotropin (HCG)-treated animals showed a peak uptake in reserve cells comparable to that of late proestrus/early estrus. Estradiol-treated animals showed an uptake pattern into secretory cells comparable to the pattern seen in late estrus/metestrus-1. Progesterone-treated animals showed a return to predominantly reserve cell uptake similar to that of the late cycle, metestrus-2/diestrus. These cyclic changes of uptake of 3H-thymidine are interpreted as a growth-maturation-function cycle designed to sustain the egg or zygote in the tube and to replenish the tubal epithelium at the end of a cycle or pregnancy. The intercalary cells are recognized as end-stage elements of predominantly degranulated secretory cells.

UR - http://www.scopus.com/inward/record.url?scp=0015898937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015898937&partnerID=8YFLogxK

U2 - 10.1016/0002-9378(73)90110-5

DO - 10.1016/0002-9378(73)90110-5

M3 - Article

C2 - 4795495

AN - SCOPUS:0015898937

VL - 117

SP - 490

EP - 496

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 4

ER -