Autotransporter and two-partner secretion: Delivery of large-size virulence factors by gram-negative bacterial pathogens

Cheryl L. Newman, Christos Stathopoulos

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

A number of protein secretion mechanisms have been identified in gram-negative pathogens. Many of these secretion systems are dependent upon the Sec translocase for protein export from the cytoplasm into the periplasm and then utilize other mechanisms for transport from the periplasm through the outer membrane. In this article, we review secretion similarities between autotransporter and two-partner secretion systems, and we report similarities between the autotransporter secretion mechanism with that of intimin/invasins. Considering that many secreted proteins are virulence factors, a better understanding of their secretion mechanisms will aid in the development of disease treatments and new bacterial vaccines.

Original languageEnglish (US)
Pages (from-to)275-286
Number of pages12
JournalCritical Reviews in Microbiology
Volume30
Issue number4
DOIs
Publication statusPublished - Dec 8 2004
Externally publishedYes

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Keywords

  • Autotransporter
  • Gram-Negative Bacteria
  • Invasin
  • Protein Secretion
  • Two-Partner Secretion

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

Cite this

Autotransporter and two-partner secretion : Delivery of large-size virulence factors by gram-negative bacterial pathogens. / Newman, Cheryl L.; Stathopoulos, Christos.

In: Critical Reviews in Microbiology, Vol. 30, No. 4, 08.12.2004, p. 275-286.

Research output: Contribution to journalReview article