TY - JOUR
T1 - Autotransporter and two-partner secretion
T2 - Delivery of large-size virulence factors by gram-negative bacterial pathogens
AU - Newman, Cheryl L.
AU - Stathopoulos, Christos
N1 - Funding Information:
We would like to thank Dr. Rachel Fernandez and Maria Kostakioti for critical review of this manuscript and Robert Bradley for his aid in generating the figures within this work. This project has been funded by research grants from NIH, USDA, and the Welch Foundation (E-1548).
PY - 2004
Y1 - 2004
N2 - A number of protein secretion mechanisms have been identified in gram-negative pathogens. Many of these secretion systems are dependent upon the Sec translocase for protein export from the cytoplasm into the periplasm and then utilize other mechanisms for transport from the periplasm through the outer membrane. In this article, we review secretion similarities between autotransporter and two-partner secretion systems, and we report similarities between the autotransporter secretion mechanism with that of intimin/invasins. Considering that many secreted proteins are virulence factors, a better understanding of their secretion mechanisms will aid in the development of disease treatments and new bacterial vaccines.
AB - A number of protein secretion mechanisms have been identified in gram-negative pathogens. Many of these secretion systems are dependent upon the Sec translocase for protein export from the cytoplasm into the periplasm and then utilize other mechanisms for transport from the periplasm through the outer membrane. In this article, we review secretion similarities between autotransporter and two-partner secretion systems, and we report similarities between the autotransporter secretion mechanism with that of intimin/invasins. Considering that many secreted proteins are virulence factors, a better understanding of their secretion mechanisms will aid in the development of disease treatments and new bacterial vaccines.
KW - Autotransporter
KW - Gram-Negative Bacteria
KW - Invasin
KW - Protein Secretion
KW - Two-Partner Secretion
UR - http://www.scopus.com/inward/record.url?scp=9344245722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9344245722&partnerID=8YFLogxK
U2 - 10.1080/10408410490499872
DO - 10.1080/10408410490499872
M3 - Review article
C2 - 15646401
AN - SCOPUS:9344245722
SN - 1040-841X
VL - 30
SP - 275
EP - 286
JO - Critical Reviews in Microbiology
JF - Critical Reviews in Microbiology
IS - 4
ER -
