B Cell Disorders in Children—Part I

Bailee Gilchrist, William K. Dolen

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Purpose of Review: The advent of enhanced genetic testing has allowed for the discovery of gene defects underlying two broad categories of antibody deficiency in children: agammaglobulinemia and common variable immunodeficiency (CVID). This review describes the underlying gene defects and the clinical manifestations. Recent Findings: Because novel monogenetic defects have been discovered in both categories, a strict dichotomous classification of B cell disorders as either X-linked agammaglobulinemia or common variable immunodeficiency is no longer appropriate. Summary: Advances in genetic testing technology and the decreasing cost of such testing permit more precise diagnosis of B cell disorders, more helpful information for genetic counselors, and a better understanding of the complex process of B cell development and function. More disorders await discovery.

Original languageEnglish (US)
Article number52
JournalCurrent Allergy and Asthma Reports
Volume20
Issue number9
DOIs
StatePublished - Sep 1 2020

Keywords

  • Agammaglobulinemia
  • Antibody deficiency
  • B cell disorders
  • Common variable immunodeficiency
  • Immunodeficiency in children

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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