BAG-1, an anti-apoptotic tumour marker

Shou-Ching Tang

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

BAG-1 is a multifunctional and anti-apoptotic or anti-cell death protein that interacts with a variety of cellular proteins and affects their functions. On the cell surface, it binds to the cytosolic domain of the growth factor receptors and enhances the protection from cell death triggered by growth factor receptors. In the cytosol, it binds to Bcl-2 and heat shock protein, and modulates their functions. In the nucleus, it binds to a variety of nuclear hormone receptors and inhibits hormone-induced apoptosis. BAG-1 is widely overexpressed in a variety of tumour cell lines and cancer tissues. In addition, differential expression of BAG-1 isoforms has been observed. Preclinical studies indicate that overexpression of BAG-1, especially its nuclear and cytoplasmic isoforms, may be useful as a prognostic and/or predictive biomarker. Pilot clinical studies have demonstrated that overexpression of nuclear BAG-1 may be associated with a shorter survival in breast and laryngeal carcinomas. Conversely, overexpression of cytoplasmic BAG-1 may be associated with a better clinical outcome in early stage breast cancer and in non-small cell lung cancer. Further large-scale clinical studies are warranted to establish the role of BAG-1 as a novel prognostic and/or predictive biomarker in the clinical management of these common malignancies.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalIUBMB Life
Volume53
Issue number2
DOIs
StatePublished - Jun 4 2002

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Growth Factor Receptors
Biomarkers
Cell death
Tumor Biomarkers
Protein Isoforms
Cell Death
Cells
Breast Neoplasms
Cytoplasmic and Nuclear Receptors
Heat-Shock Proteins
Tumor Cell Line
Non-Small Cell Lung Carcinoma
Cytosol
Tumors
Neoplasms
Proteins
Hormones
Tissue
Apoptosis
Clinical Studies

Keywords

  • Apoptosis
  • BAG-1
  • Breast cancer
  • Laryngeal cancer
  • Lung cancer
  • Oral cancer
  • Prognosis and biomarker
  • Review

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

BAG-1, an anti-apoptotic tumour marker. / Tang, Shou-Ching.

In: IUBMB Life, Vol. 53, No. 2, 04.06.2002, p. 99-105.

Research output: Contribution to journalReview article

Tang, Shou-Ching. / BAG-1, an anti-apoptotic tumour marker. In: IUBMB Life. 2002 ; Vol. 53, No. 2. pp. 99-105.
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