BDNF-TrkB signaling and neuroprotection in schizophrenia

Chirayukumar D Pandya, Ammar Kutiyanawalla, Anilkumar R Pillai

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Neurotrophins such as brain-derived neurotropic factor (BDNF), play critical role in neuronal survival, synaptic plasticity and cognitive functions. BDNF is known to mediate its action through various intracellular signaling pathways triggered by activation of tyrosine kinase receptor B (TrkB). Evidence from clinical as well pre-clinical studies indicate alterations in BDNF signaling in schizophrenia. Moreover, several antipsychotic drugs have time-dependent effects on BDNF levels in both schizophrenia subjects and animal models of schizophrenia. Given the emerging interest in neuroplasticity in schizophrenia understanding the neuroprotective and cell survival roles of BDNF signaling will enhance our knowledge of its diverse effects, which may lead to more effective treatments for schizophrenia. This article will present an overview of recent findings on the role of BDNF signaling in the pathophysiology and treatment of schizophrenia, with a special focus on its neuroprotective effects.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalAsian Journal of Psychiatry
Volume6
Issue number1
DOIs
StatePublished - Feb 1 2013

Fingerprint

Receptor Protein-Tyrosine Kinases
Schizophrenia
Brain
Neuronal Plasticity
Nerve Growth Factors
Neuroprotective Agents
Cognition
Antipsychotic Agents
Neuroprotection
Cell Survival
Animal Models

Keywords

  • Antipsychotic
  • Brain-derived neurotrophic factor (BDNF)
  • Neuroprotection
  • Schizophrenia
  • Tyrosine kinase receptor B (TrkB)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

BDNF-TrkB signaling and neuroprotection in schizophrenia. / Pandya, Chirayukumar D; Kutiyanawalla, Ammar; Pillai, Anilkumar R.

In: Asian Journal of Psychiatry, Vol. 6, No. 1, 01.02.2013, p. 22-28.

Research output: Contribution to journalReview article

Pandya, Chirayukumar D ; Kutiyanawalla, Ammar ; Pillai, Anilkumar R. / BDNF-TrkB signaling and neuroprotection in schizophrenia. In: Asian Journal of Psychiatry. 2013 ; Vol. 6, No. 1. pp. 22-28.
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