Behavioral reinforcement of long-term potentiation is impaired in aged rats with cognitive deficiencies

J. A. Bergado, W. Almaguer, J. Ravelo, J. C. Rosillo, Julietta Uta Frey

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Behavioral stimuli with emotional/motivational content can reinforce long-term potentiation in the dentate gyrus, if presented within a distinct time window. A similar effect can be obtained by stimulating the basolateral amygdala, a limbic structure related to emotions. We have previously shown that aging impairs amygdala-hippocampus interactions during long-term potentiation. In this report we show that behavioral reinforcement of long-term potentiation is also impaired in aged rats with cognitive deficits. While among young water-deprived animals drinking 15 min after induction of long-term potentiation leads to a significant prolongation of potentiation, cognitively impaired aged rats are devoid of such reinforcing effects. In contrast, a slight but statistically significant depression develops after drinking in this group of animals. We suggest that an impaired mechanism of emotional/motivational reinforcement of synaptic plasticity might be functionally related to the cognitive deficits shown by aged animals.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalNeuroscience
Volume108
Issue number1
DOIs
StatePublished - Dec 5 2001

Fingerprint

Long-Term Potentiation
Drinking
Neuronal Plasticity
Dentate Gyrus
Amygdala
Hippocampus
Emotions
Depression
Reinforcement (Psychology)
Water

Keywords

  • Aging
  • Cognitive impairment
  • Dentate gyrus
  • Learning
  • Long-term potentiation
  • Reinforcement

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Behavioral reinforcement of long-term potentiation is impaired in aged rats with cognitive deficiencies. / Bergado, J. A.; Almaguer, W.; Ravelo, J.; Rosillo, J. C.; Frey, Julietta Uta.

In: Neuroscience, Vol. 108, No. 1, 05.12.2001, p. 1-5.

Research output: Contribution to journalArticle

Bergado, J. A. ; Almaguer, W. ; Ravelo, J. ; Rosillo, J. C. ; Frey, Julietta Uta. / Behavioral reinforcement of long-term potentiation is impaired in aged rats with cognitive deficiencies. In: Neuroscience. 2001 ; Vol. 108, No. 1. pp. 1-5.
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