Benign fibroblastic polyps of the colon

Aaron R. Huber, James F Shikle

Research output: Contribution to journalShort survey

11 Citations (Scopus)

Abstract

Benign fibroblastic polyps of the colon are a recently described entity among mucosal polyps found in the colorectum. These polyps are typically discovered on routine screening colonoscopy within the distal colon. Benign fi-broblastic polyps occur most commonly in adult women in the sixth decade of life. Histologically, benign fibroblastic polyps are bland spindle cell lesions that fill the lamina propria and displace the surrounding crypts. The spindle cell proliferation lacks atypia and significant mitotic activity. Hyperplastic changes are frequently present both in the adjacent epithelium and within the lesions. Immunohistochemically, the cells of benign fibroblastic polyps are invariably positive for vimentin with rare focal positivity for CD34 and smooth muscle actin. They are negative for CD117 and S100 protein. Ultrastructurally, benign fibroblastic polyps have features of fibroblastic differentiation. These polyps are benign with no reports, to our knowledge, of recurrence or metastasis.

Original languageEnglish (US)
Pages (from-to)1872-1876
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume133
Issue number11
StatePublished - Nov 1 2009
Externally publishedYes

Fingerprint

Polyps
Colon
S100 Proteins
Vimentin
Colonoscopy
Smooth Muscle
Actins
Mucous Membrane
Epithelium
Cell Proliferation
Neoplasm Metastasis
Recurrence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Benign fibroblastic polyps of the colon. / Huber, Aaron R.; Shikle, James F.

In: Archives of Pathology and Laboratory Medicine, Vol. 133, No. 11, 01.11.2009, p. 1872-1876.

Research output: Contribution to journalShort survey

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