Beyond antibody-mediated rejection: Hyperacute lung rejection as a paradigm for dysregulated inflammation

Bao H. Nguyen, Egon Zwets, Carsten Schroeder, Richard N. Pierson, Agnes M. Azimzadeh

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

The use of animal organs for transplantation in humans is seen as a potential solution to the short supply of human donor organs available for clinical transplantation. However, to develop this therapeutic option as clinical reality will require surmounting formidable obstacles. The primary immunologic barrier to pig-to-human xenotransplantation is hyperacute rejection (HAR), a phenomenon previously characterized as resulting from antibody binding and complement activation. This article will first review recent progress in the development of specific strategies to overcome hyperacute lung rejection (HALR), through production of genetically engineered pig organs, modification of the host innate immunity and control of antibody and complement. Additional therapeutic targets identified in HALR are reviewed, with particular emphasis on recent studies describing a critical role for the coagulation cascade in HAR.

Original languageEnglish (US)
Pages (from-to)255-269
Number of pages15
JournalCurrent Drug Targets - Cardiovascular and Haematological Disorders
Volume5
Issue number3
DOIs
StatePublished - Jun 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Hematology
  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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