Bilateral prophylactic mastectomy: issues and concerns.

M. E. Stefanek

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

At present, the care of women at increased risk of developing breast cancer poses a clinical dilemma and remains an area of controversy. A number of investigators have addressed the pros and cons of prophylactic mastectomy versus close follow-up, utilizing annual mammography, semiannual or even more frequent physical examinations of the breast, and proficient monthly breast self-examinations. Recent efforts to isolate a gene (BRCA1) on chromosome 17q12-21 raise additional concerns about the management of women testing positive for BRCA1 mutations. These women are estimated to have an 85% lifetime risk of developing breast cancer. Testing for BRCA1 mutation carriers may soon be available for population screening. This article describes preliminary studies investigating health care provider and patient perceptions of bilateral prophylactic mastectomy. In addition, a number of research questions remain regarding the efficacy and utilization of bilateral prophylactic mastectomy as a treatment option for women at increased risk of developing breast cancer. These women include those testing positive for BRCA1 mutations. In addition, women with a strong family history opting against testing for BRCA1 mutations may express interest in surgery.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalJournal of the National Cancer Institute. Monographs
Issue number17
StatePublished - 1995

Fingerprint

Mutation
Breast Neoplasms
Breast Self-Examination
BRCA1 Gene
Chromosomes, Human, Pair 21
Mammography
Health Personnel
Physical Examination
Prophylactic Mastectomy
Breast
Research Personnel
Research
Population
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bilateral prophylactic mastectomy : issues and concerns. / Stefanek, M. E.

In: Journal of the National Cancer Institute. Monographs, No. 17, 1995, p. 37-42.

Research output: Contribution to journalReview article

@article{5a6068234c464aa183007795a24af69f,
title = "Bilateral prophylactic mastectomy: issues and concerns.",
abstract = "At present, the care of women at increased risk of developing breast cancer poses a clinical dilemma and remains an area of controversy. A number of investigators have addressed the pros and cons of prophylactic mastectomy versus close follow-up, utilizing annual mammography, semiannual or even more frequent physical examinations of the breast, and proficient monthly breast self-examinations. Recent efforts to isolate a gene (BRCA1) on chromosome 17q12-21 raise additional concerns about the management of women testing positive for BRCA1 mutations. These women are estimated to have an 85{\%} lifetime risk of developing breast cancer. Testing for BRCA1 mutation carriers may soon be available for population screening. This article describes preliminary studies investigating health care provider and patient perceptions of bilateral prophylactic mastectomy. In addition, a number of research questions remain regarding the efficacy and utilization of bilateral prophylactic mastectomy as a treatment option for women at increased risk of developing breast cancer. These women include those testing positive for BRCA1 mutations. In addition, women with a strong family history opting against testing for BRCA1 mutations may express interest in surgery.",
author = "Stefanek, {M. E.}",
year = "1995",
language = "English (US)",
pages = "37--42",
journal = "NCI Monographs",
issn = "1052-6773",
publisher = "Oxford University Press",
number = "17",

}

TY - JOUR

T1 - Bilateral prophylactic mastectomy

T2 - issues and concerns.

AU - Stefanek, M. E.

PY - 1995

Y1 - 1995

N2 - At present, the care of women at increased risk of developing breast cancer poses a clinical dilemma and remains an area of controversy. A number of investigators have addressed the pros and cons of prophylactic mastectomy versus close follow-up, utilizing annual mammography, semiannual or even more frequent physical examinations of the breast, and proficient monthly breast self-examinations. Recent efforts to isolate a gene (BRCA1) on chromosome 17q12-21 raise additional concerns about the management of women testing positive for BRCA1 mutations. These women are estimated to have an 85% lifetime risk of developing breast cancer. Testing for BRCA1 mutation carriers may soon be available for population screening. This article describes preliminary studies investigating health care provider and patient perceptions of bilateral prophylactic mastectomy. In addition, a number of research questions remain regarding the efficacy and utilization of bilateral prophylactic mastectomy as a treatment option for women at increased risk of developing breast cancer. These women include those testing positive for BRCA1 mutations. In addition, women with a strong family history opting against testing for BRCA1 mutations may express interest in surgery.

AB - At present, the care of women at increased risk of developing breast cancer poses a clinical dilemma and remains an area of controversy. A number of investigators have addressed the pros and cons of prophylactic mastectomy versus close follow-up, utilizing annual mammography, semiannual or even more frequent physical examinations of the breast, and proficient monthly breast self-examinations. Recent efforts to isolate a gene (BRCA1) on chromosome 17q12-21 raise additional concerns about the management of women testing positive for BRCA1 mutations. These women are estimated to have an 85% lifetime risk of developing breast cancer. Testing for BRCA1 mutation carriers may soon be available for population screening. This article describes preliminary studies investigating health care provider and patient perceptions of bilateral prophylactic mastectomy. In addition, a number of research questions remain regarding the efficacy and utilization of bilateral prophylactic mastectomy as a treatment option for women at increased risk of developing breast cancer. These women include those testing positive for BRCA1 mutations. In addition, women with a strong family history opting against testing for BRCA1 mutations may express interest in surgery.

UR - http://www.scopus.com/inward/record.url?scp=0029441472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029441472&partnerID=8YFLogxK

M3 - Review article

C2 - 8573451

AN - SCOPUS:0029441472

SP - 37

EP - 42

JO - NCI Monographs

JF - NCI Monographs

SN - 1052-6773

IS - 17

ER -