Abstract
Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 93-109 |
| Number of pages | 17 |
| Journal | British Journal of Pharmacology |
| Volume | 176 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2019 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Bioactive lipids and pathological retinal angiogenesis. / Elmasry, Khaled; Ibrahim, Ahmed S.; Abdulmoneim, Samer; Al-Shabrawey, Mohamed.
In: British Journal of Pharmacology, Vol. 176, No. 1, 01.2019, p. 93-109.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Bioactive lipids and pathological retinal angiogenesis
AU - Elmasry, Khaled
AU - Ibrahim, Ahmed S.
AU - Abdulmoneim, Samer
AU - Al-Shabrawey, Mohamed
PY - 2019/1
Y1 - 2019/1
N2 - Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.
AB - Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.
UR - http://www.scopus.com/inward/record.url?scp=85056693040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056693040&partnerID=8YFLogxK
U2 - 10.1111/bph.14507
DO - 10.1111/bph.14507
M3 - Review article
C2 - 30276789
AN - SCOPUS:85056693040
VL - 176
SP - 93
EP - 109
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 1
ER -