Bioactive lipids and pathological retinal angiogenesis

Khaled Elmasry, Ahmed Salah Ibrahim, Samer Abdulmoneim, Mohamed Al-Shabrawey

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.

Original languageEnglish (US)
Pages (from-to)93-109
Number of pages17
JournalBritish Journal of Pharmacology
Volume176
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Pathologic Neovascularization
Unsaturated Fatty Acids
Retina
Lipids
Retinopathy of Prematurity
Macular Degeneration
Diabetic Retinopathy
Edema
Blood Cells
Leukocytes
vascular factor

ASJC Scopus subject areas

  • Pharmacology

Cite this

Bioactive lipids and pathological retinal angiogenesis. / Elmasry, Khaled; Ibrahim, Ahmed Salah; Abdulmoneim, Samer; Al-Shabrawey, Mohamed.

In: British Journal of Pharmacology, Vol. 176, No. 1, 01.01.2019, p. 93-109.

Research output: Contribution to journalReview article

Elmasry, Khaled ; Ibrahim, Ahmed Salah ; Abdulmoneim, Samer ; Al-Shabrawey, Mohamed. / Bioactive lipids and pathological retinal angiogenesis. In: British Journal of Pharmacology. 2019 ; Vol. 176, No. 1. pp. 93-109.
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