Bioactive lipids and pathological retinal angiogenesis

Khaled Elmasry; Ahmed S. Ibrahim; Samer Abdulmoneim; Mohamed Al-Shabrawey

doi:10.1111/bph.14507

Bioactive lipids and pathological retinal angiogenesis

Khaled Elmasry, Ahmed S. Ibrahim, Samer Abdulmoneim, Mohamed Al-Shabrawey

Oral Biology & Dx Sciences

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.

Original language	English (US)
Pages (from-to)	93-109
Number of pages	17
Journal	British Journal of Pharmacology
Volume	176
Issue number	1
DOIs	https://doi.org/10.1111/bph.14507
State	Published - Jan 2019

ASJC Scopus subject areas

Pharmacology

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title = "Bioactive lipids and pathological retinal angiogenesis",

abstract = "Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.",

author = "Khaled Elmasry and Ibrahim, {Ahmed S.} and Samer Abdulmoneim and Mohamed Al-Shabrawey",

note = "Funding Information: This work has been supported by the National Eye Institute grant R01EY023315 (MA) and the American Heart Association grant 18CDA34080403 (ASI). Publisher Copyright: {\textcopyright} 2018 The British Pharmacological Society",

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AU - Ibrahim, Ahmed S.

AU - Abdulmoneim, Samer

AU - Al-Shabrawey, Mohamed

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N2 - Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.

AB - Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.

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Bioactive lipids and pathological retinal angiogenesis

Abstract

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