TY - JOUR
T1 - Bioactive lipids and pathological retinal angiogenesis
AU - Elmasry, Khaled
AU - Ibrahim, Ahmed Salah
AU - Abdulmoneim, Samer
AU - Al-Shabrawey, Mohamed
N1 - Funding Information:
This work has been supported by the National Eye Institute grant R01EY023315 (MA) and the American Heart Association grant 18CDA34080403 (ASI).
Publisher Copyright:
© 2018 The British Pharmacological Society
PY - 2019/1
Y1 - 2019/1
N2 - Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.
AB - Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.
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U2 - 10.1111/bph.14507
DO - 10.1111/bph.14507
M3 - Review article
C2 - 30276789
AN - SCOPUS:85056693040
VL - 176
SP - 93
EP - 109
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 1
ER -