Birth weight and asthma incidence by asthma phenotype pattern in a racially diverse cohort followed through adolescence

Christine Cole Johnson, Edward L. Peterson, Christine L M Joseph, Dennis Randall Ownby, Naomi Breslau

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Low birth weight (LBW) has been shown to be an independent risk factor for asthma. We hypothesized that LBW would have its greatest impact on early onset disease. Methods: A racially diverse cohort of children born from 1983 to 1985 at two hospitals, one urban and one suburban in the same metropolitan area, and oversampled for babies weighing ≤2500 g, was identified retrospectively when the children were 6 years of age and followed periodically. At the age 17 years study visit, cohort members and their parent/guardians were separately interviewed face-to-face regarding the subjects history of asthma using the standardized ISAAC questionnaire. We measured the cumulative incidence of asthma from birth through adolescence defined by age of diagnosis and persistence/remittance. Results: Six-hundred and eighty teens (82.6% of the original cohort) were included in the analyses, 387 with LBW and 293 of normal birth weight. The prevalence of physician-diagnosed "Current Asthma" was associated with LBW (p = 0.003 for trend), with patterns stronger in males and whites. LBW was associated most strongly with Late Onset Persistent asthma (current asthma that was diagnosed after 8 years); p for trend 0.032. This trend was again most evident in males and whites. None of the asthma categories classified as "remittent" were statistically associated with LBW. Conclusions: LBW was not associated with diagnosed asthma that remitted before age 17 years. LBW was associated with asthma diagnosis in mid-childhood that persisted through adolescence, suggesting that the asthmagenic effects of LBW can become evident post the early years of childhood and persist into adulthood.

Original languageEnglish (US)
Pages (from-to)1006-1012
Number of pages7
JournalJournal of Asthma
Volume52
Issue number10
DOIs
StatePublished - Nov 26 2015

Fingerprint

Low Birth Weight Infant
Birth Weight
Asthma
Phenotype
Incidence
Urban Hospitals
Cohort Studies
Economics
Parturition
Physicians

Keywords

  • Age of onset
  • Blacks
  • Cumulative incidence
  • ISAAC
  • Life course epidemiology
  • Pediatrics
  • Whites

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Birth weight and asthma incidence by asthma phenotype pattern in a racially diverse cohort followed through adolescence. / Johnson, Christine Cole; Peterson, Edward L.; Joseph, Christine L M; Ownby, Dennis Randall; Breslau, Naomi.

In: Journal of Asthma, Vol. 52, No. 10, 26.11.2015, p. 1006-1012.

Research output: Contribution to journalArticle

Johnson, Christine Cole ; Peterson, Edward L. ; Joseph, Christine L M ; Ownby, Dennis Randall ; Breslau, Naomi. / Birth weight and asthma incidence by asthma phenotype pattern in a racially diverse cohort followed through adolescence. In: Journal of Asthma. 2015 ; Vol. 52, No. 10. pp. 1006-1012.
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abstract = "Objective: Low birth weight (LBW) has been shown to be an independent risk factor for asthma. We hypothesized that LBW would have its greatest impact on early onset disease. Methods: A racially diverse cohort of children born from 1983 to 1985 at two hospitals, one urban and one suburban in the same metropolitan area, and oversampled for babies weighing ≤2500 g, was identified retrospectively when the children were 6 years of age and followed periodically. At the age 17 years study visit, cohort members and their parent/guardians were separately interviewed face-to-face regarding the subjects history of asthma using the standardized ISAAC questionnaire. We measured the cumulative incidence of asthma from birth through adolescence defined by age of diagnosis and persistence/remittance. Results: Six-hundred and eighty teens (82.6{\%} of the original cohort) were included in the analyses, 387 with LBW and 293 of normal birth weight. The prevalence of physician-diagnosed {"}Current Asthma{"} was associated with LBW (p = 0.003 for trend), with patterns stronger in males and whites. LBW was associated most strongly with Late Onset Persistent asthma (current asthma that was diagnosed after 8 years); p for trend 0.032. This trend was again most evident in males and whites. None of the asthma categories classified as {"}remittent{"} were statistically associated with LBW. Conclusions: LBW was not associated with diagnosed asthma that remitted before age 17 years. LBW was associated with asthma diagnosis in mid-childhood that persisted through adolescence, suggesting that the asthmagenic effects of LBW can become evident post the early years of childhood and persist into adulthood.",
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