Bladder tumor markers beyond cytology: International Consensus Panel on bladder tumor markers

Vinata B Lokeshwar, Tomonori Habuchi, H. Barton Grossman, William M. Murphy, Stefan H. Hautmann, George P. Hemstreet, Aldo V. Bono, Robert H. Getzenberg, Peter Goebell, Bernd J. Schmitz-Dräger, Jack A. Schalken, Yves Fradet, Michael Marberger, Edward Messing, Michael J. Droller

Research output: Contribution to journalArticle

302 Citations (Scopus)

Abstract

This is the first of 2 articles that summarize the findings of the International Consensus Panel on cytology and bladder tumor markers. The objectives of our panel were to reach a consensus on the areas where markers are needed, to define the attributes of an ideal tumor marker, and to identify which marker(s) would be suitable for diagnosis and/or surveillance of bladder cancer. Our panel consisted of urologists and researchers from Europe, Asia, and the United States who reviewed original articles, reviews, and book chapters on individual bladder tumor markers published in the English language mainly using the PubMed search engine. Panel members also met during 3 international meetings to write recommendations regarding bladder tumor markers. The panel found that the most practical use of noninvasive tests is to monitor bladder cancer recurrence, thereby reducing the number of surveillance cystoscopies performed each year. Markers also may be useful in the screening of high-risk individuals for early detection of bladder cancer. However, more prospective studies are needed to strengthen this argument. Case-control and cohort studies show that several markers have a higher sensitivity to detect bladder cancer. However, cytology is the superior marker in terms of specificity, although some markers in limited numbers of studies have shown specificity equivalent to that of cytology. Our panel believes that several bladder tumor markers are more accurate in detecting bladder cancer than prostate-specific antigen (PSA) is in detecting prostate cancer. However, bladder tumor markers are held to a higher standard than PSA. Therefore, use of bladder tumor markers in the management of patients with bladder cancer will require the willingness of both urologists and clinicians to accept them.

Original languageEnglish (US)
Pages (from-to)35-63
Number of pages29
JournalUrology
Volume66
Issue number6 SUPPL. 1
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

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Tumor Biomarkers
Urinary Bladder Neoplasms
Cell Biology
Consensus
Prostate-Specific Antigen
Prostatic Neoplasms
Search Engine
Cystoscopy
Early Detection of Cancer
PubMed
Case-Control Studies
Cohort Studies
Language
Research Personnel
Prospective Studies
Recurrence

ASJC Scopus subject areas

  • Urology

Cite this

Lokeshwar, V. B., Habuchi, T., Grossman, H. B., Murphy, W. M., Hautmann, S. H., Hemstreet, G. P., ... Droller, M. J. (2005). Bladder tumor markers beyond cytology: International Consensus Panel on bladder tumor markers. Urology, 66(6 SUPPL. 1), 35-63. https://doi.org/10.1016/j.urology.2005.08.064

Bladder tumor markers beyond cytology : International Consensus Panel on bladder tumor markers. / Lokeshwar, Vinata B; Habuchi, Tomonori; Grossman, H. Barton; Murphy, William M.; Hautmann, Stefan H.; Hemstreet, George P.; Bono, Aldo V.; Getzenberg, Robert H.; Goebell, Peter; Schmitz-Dräger, Bernd J.; Schalken, Jack A.; Fradet, Yves; Marberger, Michael; Messing, Edward; Droller, Michael J.

In: Urology, Vol. 66, No. 6 SUPPL. 1, 01.12.2005, p. 35-63.

Research output: Contribution to journalArticle

Lokeshwar, VB, Habuchi, T, Grossman, HB, Murphy, WM, Hautmann, SH, Hemstreet, GP, Bono, AV, Getzenberg, RH, Goebell, P, Schmitz-Dräger, BJ, Schalken, JA, Fradet, Y, Marberger, M, Messing, E & Droller, MJ 2005, 'Bladder tumor markers beyond cytology: International Consensus Panel on bladder tumor markers', Urology, vol. 66, no. 6 SUPPL. 1, pp. 35-63. https://doi.org/10.1016/j.urology.2005.08.064
Lokeshwar VB, Habuchi T, Grossman HB, Murphy WM, Hautmann SH, Hemstreet GP et al. Bladder tumor markers beyond cytology: International Consensus Panel on bladder tumor markers. Urology. 2005 Dec 1;66(6 SUPPL. 1):35-63. https://doi.org/10.1016/j.urology.2005.08.064
Lokeshwar, Vinata B ; Habuchi, Tomonori ; Grossman, H. Barton ; Murphy, William M. ; Hautmann, Stefan H. ; Hemstreet, George P. ; Bono, Aldo V. ; Getzenberg, Robert H. ; Goebell, Peter ; Schmitz-Dräger, Bernd J. ; Schalken, Jack A. ; Fradet, Yves ; Marberger, Michael ; Messing, Edward ; Droller, Michael J. / Bladder tumor markers beyond cytology : International Consensus Panel on bladder tumor markers. In: Urology. 2005 ; Vol. 66, No. 6 SUPPL. 1. pp. 35-63.
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