Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen

N. A. Lambert, N. L. Harrison, D. I.B. Kerr, J. Ong, R. H. Prager, T. J. Teyler

Research output: Contribution to journalArticle

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Abstract

The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potentials from CA1 hippocampal neurons. 2-Hydroxy-saclofen (50-200 μM) reversibly blocked the late, GABAB receptor-mediated inhibitory postsynaptic potential (IPSP) but not the early, GABAA receptor-mediated IPSP. In addition, the hyperpolarizing response to baclofen was reduced by similar concentrations of 2-hydroxy-saclofen. This suggests that 2-hydroxy-saclofen is a potent antagonist at postsynaptic GABAB receptors on hippocampal neurons.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalNeuroscience Letters
Volume107
Issue number1-3
DOIs
StatePublished - Dec 15 1989
Externally publishedYes

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Keywords

  • 2-Hydroxy-saclofen
  • Rat hippocampal slice
  • Slow inhibitory postsynaptic potential
  • γ-Aminobutyric acid-B receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lambert, N. A., Harrison, N. L., Kerr, D. I. B., Ong, J., Prager, R. H., & Teyler, T. J. (1989). Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen. Neuroscience Letters, 107(1-3), 125-128. https://doi.org/10.1016/0304-3940(89)90803-3