Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen

Nevin A Lambert, N. L. Harrison, D. I.B. Kerr, J. Ong, R. H. Prager, T. J. Teyler

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potentials from CA1 hippocampal neurons. 2-Hydroxy-saclofen (50-200 μM) reversibly blocked the late, GABAB receptor-mediated inhibitory postsynaptic potential (IPSP) but not the early, GABAA receptor-mediated IPSP. In addition, the hyperpolarizing response to baclofen was reduced by similar concentrations of 2-hydroxy-saclofen. This suggests that 2-hydroxy-saclofen is a potent antagonist at postsynaptic GABAB receptors on hippocampal neurons.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalNeuroscience Letters
Volume107
Issue number1-3
DOIs
StatePublished - Dec 15 1989
Externally publishedYes

Fingerprint

Inhibitory Postsynaptic Potentials
Neurons
Synaptic Potentials
Baclofen
GABA-A Receptors
2-hydroxysaclofen

Keywords

  • 2-Hydroxy-saclofen
  • Rat hippocampal slice
  • Slow inhibitory postsynaptic potential
  • γ-Aminobutyric acid-B receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lambert, N. A., Harrison, N. L., Kerr, D. I. B., Ong, J., Prager, R. H., & Teyler, T. J. (1989). Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen. Neuroscience Letters, 107(1-3), 125-128. https://doi.org/10.1016/0304-3940(89)90803-3

Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen. / Lambert, Nevin A; Harrison, N. L.; Kerr, D. I.B.; Ong, J.; Prager, R. H.; Teyler, T. J.

In: Neuroscience Letters, Vol. 107, No. 1-3, 15.12.1989, p. 125-128.

Research output: Contribution to journalArticle

Lambert, NA, Harrison, NL, Kerr, DIB, Ong, J, Prager, RH & Teyler, TJ 1989, 'Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen', Neuroscience Letters, vol. 107, no. 1-3, pp. 125-128. https://doi.org/10.1016/0304-3940(89)90803-3
Lambert, Nevin A ; Harrison, N. L. ; Kerr, D. I.B. ; Ong, J. ; Prager, R. H. ; Teyler, T. J. / Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen. In: Neuroscience Letters. 1989 ; Vol. 107, No. 1-3. pp. 125-128.
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