Blood flow regulation and oxidative stress during submaximal cycling exercise in patients with cystic fibrosis

Matthew A. Tucker, Breana Berry, Nichole Seigler, Gareth W. Davison, John C. Quindry, Dabney Eidson, Kathleen T McKie, Ryan A. Harris

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: The impact of blood flow regulation and oxidative stress during exercise in cystic fibrosis (CF) has yet to be investigated. Methods: A maximal graded exercise test was conducted to determine exercise capacity (VO 2 peak) and peak workload in 14 pediatric patients with mild CF (age 14 ± 3 y, FEV 1 93 ± 16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performed submaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde and antegrade components were further analyzed as indices of blood flow regulation. Results: The cumulative AUC for retrograde velocity was lower in patients versus controls (1770 ± 554 vs. 3440 ± 522 cm, P = 0.038). In addition, an exaggerated oxidative stress response during exercise occurred in patients only (P = 0.004). Conclusion: These data suggest that patients with mild CF exhibit impaired blood flow regulation and an exaggerated oxidative stress response to submaximal exercise.

Original languageEnglish (US)
Pages (from-to)256-263
Number of pages8
JournalJournal of Cystic Fibrosis
Volume17
Issue number2
DOIs
StatePublished - Mar 2018

Keywords

  • Electron paramagnetic resonance spectroscopy
  • Exercise intolerance
  • Reactive oxygen species
  • Retrograde velocity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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