Blood Pressure Early in Diabetes Depends on a Balance Between Glomerular Filtration Rate and the Renin-Angiotensin System

Modesto Antonio Rojas, Tracy D. Bell, LaShon Sturgis, Vanessa Springfield, Rajiv Janardhanan, Cassandra Fleming, Michael W Brands

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Onset of diabetes increases plasma renin activity (PRA) and glomerular filtration rate (GFR), but blood pressure (BP) is normal. In this study, a 70% surgical reduction in kidney mass (RK) was used to decrease baseline GFR and to prevent hyperfiltration during diabetes, and angiotensin converting enzyme inhibitors (ACEI) were used to inhibit angiotensin II (AngII) production, to test the hypothesis that a balance between GFR and AngII is required for normal BP early in diabetes. Diabetes was induced with streptozotocin (STZ) (35 mg/kg intravenously); and after 7 days of hyperglycemia (range: 408 to 486 mg/dL), insulin was intravenously infused continuously for a 4-day normoglycemic recovery period. In normal kidney (NK) rats, diabetes increased PRA (2.4 ± 0.6 to 4.6 ± 0.5 ngAI/mL/h) and GFR (2.9 ± 0.1 to 3.5 ± 0.2 mL/min), and there was no change in mean arterial pressure (MAP) (89 ± 1 v 91 ± 1 mm Hg, measured 18 h/day). There was no change in either GFR or AngII during diabetes in RK+ACEI rats, and their MAP also did not change. Thus, the maintenance of normal MAP was accompanied by a balance between GFR and AngII in both of those groups. In NK+ACEI rats, however, GFR increased significantly with no change in AngII, and MAP decreased significantly during diabetes by ∼ 8 mm Hg. In RK rats, PRA increased (0.5 ± 0.1 to 2.6 ± 0.5) but GFR did not increase, and MAP increased significantly by ∼ 16 mm Hg. All rats were in sodium balance by day 4 of diabetes. These data support the hypothesis that normotension early in diabetes requires a balance between the increased AngII and GFR, and that BP will increase if AngII increases but GFR does not.

Original languageEnglish (US)
Pages (from-to)1249-1255
Number of pages7
JournalAmerican Journal of Hypertension
Volume19
Issue number12
DOIs
StatePublished - Dec 1 2006

Fingerprint

Renin-Angiotensin System
Glomerular Filtration Rate
Blood Pressure
Angiotensin II
Arterial Pressure
Angiotensin-Converting Enzyme Inhibitors
Renin
Kidney
Streptozocin
Hyperglycemia
Sodium
Maintenance
Insulin

Keywords

  • blood pressure
  • Diabetes
  • glomerular filtration rate
  • renin-angiotensin system
  • sodium balance

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Blood Pressure Early in Diabetes Depends on a Balance Between Glomerular Filtration Rate and the Renin-Angiotensin System. / Rojas, Modesto Antonio; Bell, Tracy D.; Sturgis, LaShon; Springfield, Vanessa; Janardhanan, Rajiv; Fleming, Cassandra; Brands, Michael W.

In: American Journal of Hypertension, Vol. 19, No. 12, 01.12.2006, p. 1249-1255.

Research output: Contribution to journalArticle

@article{709320bbbc6243bebc9025aaff0c7575,
title = "Blood Pressure Early in Diabetes Depends on a Balance Between Glomerular Filtration Rate and the Renin-Angiotensin System",
abstract = "Onset of diabetes increases plasma renin activity (PRA) and glomerular filtration rate (GFR), but blood pressure (BP) is normal. In this study, a 70{\%} surgical reduction in kidney mass (RK) was used to decrease baseline GFR and to prevent hyperfiltration during diabetes, and angiotensin converting enzyme inhibitors (ACEI) were used to inhibit angiotensin II (AngII) production, to test the hypothesis that a balance between GFR and AngII is required for normal BP early in diabetes. Diabetes was induced with streptozotocin (STZ) (35 mg/kg intravenously); and after 7 days of hyperglycemia (range: 408 to 486 mg/dL), insulin was intravenously infused continuously for a 4-day normoglycemic recovery period. In normal kidney (NK) rats, diabetes increased PRA (2.4 ± 0.6 to 4.6 ± 0.5 ngAI/mL/h) and GFR (2.9 ± 0.1 to 3.5 ± 0.2 mL/min), and there was no change in mean arterial pressure (MAP) (89 ± 1 v 91 ± 1 mm Hg, measured 18 h/day). There was no change in either GFR or AngII during diabetes in RK+ACEI rats, and their MAP also did not change. Thus, the maintenance of normal MAP was accompanied by a balance between GFR and AngII in both of those groups. In NK+ACEI rats, however, GFR increased significantly with no change in AngII, and MAP decreased significantly during diabetes by ∼ 8 mm Hg. In RK rats, PRA increased (0.5 ± 0.1 to 2.6 ± 0.5) but GFR did not increase, and MAP increased significantly by ∼ 16 mm Hg. All rats were in sodium balance by day 4 of diabetes. These data support the hypothesis that normotension early in diabetes requires a balance between the increased AngII and GFR, and that BP will increase if AngII increases but GFR does not.",
keywords = "blood pressure, Diabetes, glomerular filtration rate, renin-angiotensin system, sodium balance",
author = "Rojas, {Modesto Antonio} and Bell, {Tracy D.} and LaShon Sturgis and Vanessa Springfield and Rajiv Janardhanan and Cassandra Fleming and Brands, {Michael W}",
year = "2006",
month = "12",
day = "1",
doi = "10.1016/j.amjhyper.2006.05.012",
language = "English (US)",
volume = "19",
pages = "1249--1255",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Blood Pressure Early in Diabetes Depends on a Balance Between Glomerular Filtration Rate and the Renin-Angiotensin System

AU - Rojas, Modesto Antonio

AU - Bell, Tracy D.

AU - Sturgis, LaShon

AU - Springfield, Vanessa

AU - Janardhanan, Rajiv

AU - Fleming, Cassandra

AU - Brands, Michael W

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Onset of diabetes increases plasma renin activity (PRA) and glomerular filtration rate (GFR), but blood pressure (BP) is normal. In this study, a 70% surgical reduction in kidney mass (RK) was used to decrease baseline GFR and to prevent hyperfiltration during diabetes, and angiotensin converting enzyme inhibitors (ACEI) were used to inhibit angiotensin II (AngII) production, to test the hypothesis that a balance between GFR and AngII is required for normal BP early in diabetes. Diabetes was induced with streptozotocin (STZ) (35 mg/kg intravenously); and after 7 days of hyperglycemia (range: 408 to 486 mg/dL), insulin was intravenously infused continuously for a 4-day normoglycemic recovery period. In normal kidney (NK) rats, diabetes increased PRA (2.4 ± 0.6 to 4.6 ± 0.5 ngAI/mL/h) and GFR (2.9 ± 0.1 to 3.5 ± 0.2 mL/min), and there was no change in mean arterial pressure (MAP) (89 ± 1 v 91 ± 1 mm Hg, measured 18 h/day). There was no change in either GFR or AngII during diabetes in RK+ACEI rats, and their MAP also did not change. Thus, the maintenance of normal MAP was accompanied by a balance between GFR and AngII in both of those groups. In NK+ACEI rats, however, GFR increased significantly with no change in AngII, and MAP decreased significantly during diabetes by ∼ 8 mm Hg. In RK rats, PRA increased (0.5 ± 0.1 to 2.6 ± 0.5) but GFR did not increase, and MAP increased significantly by ∼ 16 mm Hg. All rats were in sodium balance by day 4 of diabetes. These data support the hypothesis that normotension early in diabetes requires a balance between the increased AngII and GFR, and that BP will increase if AngII increases but GFR does not.

AB - Onset of diabetes increases plasma renin activity (PRA) and glomerular filtration rate (GFR), but blood pressure (BP) is normal. In this study, a 70% surgical reduction in kidney mass (RK) was used to decrease baseline GFR and to prevent hyperfiltration during diabetes, and angiotensin converting enzyme inhibitors (ACEI) were used to inhibit angiotensin II (AngII) production, to test the hypothesis that a balance between GFR and AngII is required for normal BP early in diabetes. Diabetes was induced with streptozotocin (STZ) (35 mg/kg intravenously); and after 7 days of hyperglycemia (range: 408 to 486 mg/dL), insulin was intravenously infused continuously for a 4-day normoglycemic recovery period. In normal kidney (NK) rats, diabetes increased PRA (2.4 ± 0.6 to 4.6 ± 0.5 ngAI/mL/h) and GFR (2.9 ± 0.1 to 3.5 ± 0.2 mL/min), and there was no change in mean arterial pressure (MAP) (89 ± 1 v 91 ± 1 mm Hg, measured 18 h/day). There was no change in either GFR or AngII during diabetes in RK+ACEI rats, and their MAP also did not change. Thus, the maintenance of normal MAP was accompanied by a balance between GFR and AngII in both of those groups. In NK+ACEI rats, however, GFR increased significantly with no change in AngII, and MAP decreased significantly during diabetes by ∼ 8 mm Hg. In RK rats, PRA increased (0.5 ± 0.1 to 2.6 ± 0.5) but GFR did not increase, and MAP increased significantly by ∼ 16 mm Hg. All rats were in sodium balance by day 4 of diabetes. These data support the hypothesis that normotension early in diabetes requires a balance between the increased AngII and GFR, and that BP will increase if AngII increases but GFR does not.

KW - blood pressure

KW - Diabetes

KW - glomerular filtration rate

KW - renin-angiotensin system

KW - sodium balance

UR - http://www.scopus.com/inward/record.url?scp=33845269936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845269936&partnerID=8YFLogxK

U2 - 10.1016/j.amjhyper.2006.05.012

DO - 10.1016/j.amjhyper.2006.05.012

M3 - Article

VL - 19

SP - 1249

EP - 1255

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 12

ER -