Bone Formation and Reosseointegration in Peri-implantitis Defects Following Surgical Implantation of rhBMP-2

Oliver Hanisch, Dimitris N.tatakis, Milos M. Boskovic, Michael D. Rohrer, Ulf M E Wikesjö

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

This study was designed to evaluate bone formation and reosseointegration following surgical implantation of recombinant human bone morphogenetic protein-2 (rhBMP-2) in peri-implantitis defects. Hydroxyapatite-coated dental implants were placed bilaterally in the mandibular and maxillary premolar area in four rhesus monkeys and were allowed to osseointegrate for 1 year. Cotton ligatures were then placed around the healing abutments, and plaque was allowed to accumulate for 11 months. Resulting circumferential peri-implantitis defects exhibited a large intrabony and horizontal component. At reconstructive surgery, peri-implantitis defects in contralateral jaw quadrants were randomly assigned to receive rhBMP-2 (0.43 mg/mL implant volume) in an absorbable collagen sponge carrier or a carrier control. The animals were sacrificed 4 months postsurgery, and block sections were prepared for histometric analysis. Summary statistics included means calculated per animal. Paired t tests were used to evaluate differences between experimental conditions (n = 4). Defect depth amounted to 3.4 ± 0.9 mm and 3.2 ±0.9 mm for rhBMP-2 and control defects, respectively. Vertical bone gain in rhBMP-2 defects (2.6 ± 1.2 mm) was significantly greater than in controls (0.8 ±0.8 mm; P < .01). Reosseointegration within the confines of the defect for rhBMP-2 defects (29.0 ± 10.5%) differed significantly from that in the control (3.5 ± 2.5%; P < .01). Reosseointegration within the extent of newly formed bone averaged 40.0 ± 11.0% in rhBMP-2 defects as compared to 8.9 ± 7.8% in the control (P < .01). Osseointegration in resident bone amounted to 69.5 ± 6.9% and 72.6 ± 8.0% for rhBMP-2 and control defects, respectively. There is significant evidence that rhBMP-2 has potential to promote bone formation and reosseointegration in advanced peri-implantitis defects in-a demanding nonhuman primate model.

Original languageEnglish (US)
Pages (from-to)604-610
Number of pages7
JournalInternational Journal of Oral and Maxillofacial Implants
Volume12
Issue number5
StatePublished - Dec 1 1997

Fingerprint

Peri-Implantitis
Osteogenesis
Bone and Bones
Reconstructive Surgical Procedures
Osseointegration
Dental Implants
recombinant human bone morphogenetic protein-2
Bicuspid
Porifera
Durapatite
Jaw
Macaca mulatta
Primates
Ligation
Collagen

Keywords

  • Bone formation
  • Bone morphogenetic protein
  • Dental implants
  • Nonhuman primates
  • Osseointegration
  • Peri-implantitis

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Bone Formation and Reosseointegration in Peri-implantitis Defects Following Surgical Implantation of rhBMP-2. / Hanisch, Oliver; N.tatakis, Dimitris; Boskovic, Milos M.; Rohrer, Michael D.; Wikesjö, Ulf M E.

In: International Journal of Oral and Maxillofacial Implants, Vol. 12, No. 5, 01.12.1997, p. 604-610.

Research output: Contribution to journalArticle

Hanisch, Oliver ; N.tatakis, Dimitris ; Boskovic, Milos M. ; Rohrer, Michael D. ; Wikesjö, Ulf M E. / Bone Formation and Reosseointegration in Peri-implantitis Defects Following Surgical Implantation of rhBMP-2. In: International Journal of Oral and Maxillofacial Implants. 1997 ; Vol. 12, No. 5. pp. 604-610.
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