Bone-implant contact at calcium phosphate-coated and porous titanium oxide (TiUnite™)-modified oral implants

Andreas V. Xiropaidis, Mohammed Qahash, Won Hee Lim, Richard H. Shanaman, Michael D. Rohrer, Ulf M E Wikesjö, Jan Hall

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Calcium phosphate (CP)-coated implants are usually referred to as having osteoconductive properties, whereas titanium implants with a native oxide layer are considered less osteoconductive. Often smooth titanium oxides (TOs) are compared to relatively rough CP structures. The objective of this study was to evaluate osteoconduction by comparing bone-implant contact at a relatively smooth, highly crystalline CP coating with a structured, porous TO (TiUnite™)-modified surface. Material and methods: Ten adult Hound Labrador mongrel dogs were used. Four titanium implants (Nobel Biocare) with CP-coated (2) or TO-modified (2) surfaces were installed 12 weeks following mandibular premolar and molar teeth extraction. The implants were alternated within and between jaw quadrants in consecutive animals. Mucosal flaps were advanced and sutured leaving the implants in a submerged position. The animals were injected with fluorescent bone labels at 3 and 4 weeks postsurgery, and pre-euthanasia to monitor progress of bone formation. The animals were euthanized at 8 weeks postsurgery and block biopsies were prepared for histologic and histometric analysis. Results: There were no remarkable differences in bone formation and apparent bone-implant contact comparing the TO-modified and CP-coated surfaces. However, the measured average bone-implant contact was 71% and 57% (P=0.027) for TO-modified and CP-coated implants, respectively. Conclusions: We conclude that the TO surface exhibits osteoconductive properties exceeding that of the CP surface. One or several of the chemical and physical properties of the TO surface may result in the remarkable bone formation along its surface. This study indicated that crystallinity and/or chemistry may be important.

Original languageEnglish (US)
Pages (from-to)532-539
Number of pages8
JournalClinical Oral Implants Research
Volume16
Issue number5
DOIs
StatePublished - Oct 1 2005

Fingerprint

Bone and Bones
Osteogenesis
Titanium
Newfoundland and Labrador
Tooth Extraction
Bone Regeneration
Euthanasia
Bicuspid
calcium phosphate
titanium dioxide
Jaw
Oxides
Dogs
Biopsy

Keywords

  • Bone healing
  • Calcium phosphate
  • Dogs
  • Implant surfaces
  • Osseointegration
  • Titanium
  • Titanium oxide

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Xiropaidis, A. V., Qahash, M., Lim, W. H., Shanaman, R. H., Rohrer, M. D., Wikesjö, U. M. E., & Hall, J. (2005). Bone-implant contact at calcium phosphate-coated and porous titanium oxide (TiUnite™)-modified oral implants. Clinical Oral Implants Research, 16(5), 532-539. https://doi.org/10.1111/j.1600-0501.2005.01126.x

Bone-implant contact at calcium phosphate-coated and porous titanium oxide (TiUnite™)-modified oral implants. / Xiropaidis, Andreas V.; Qahash, Mohammed; Lim, Won Hee; Shanaman, Richard H.; Rohrer, Michael D.; Wikesjö, Ulf M E; Hall, Jan.

In: Clinical Oral Implants Research, Vol. 16, No. 5, 01.10.2005, p. 532-539.

Research output: Contribution to journalArticle

Xiropaidis, AV, Qahash, M, Lim, WH, Shanaman, RH, Rohrer, MD, Wikesjö, UME & Hall, J 2005, 'Bone-implant contact at calcium phosphate-coated and porous titanium oxide (TiUnite™)-modified oral implants', Clinical Oral Implants Research, vol. 16, no. 5, pp. 532-539. https://doi.org/10.1111/j.1600-0501.2005.01126.x
Xiropaidis, Andreas V. ; Qahash, Mohammed ; Lim, Won Hee ; Shanaman, Richard H. ; Rohrer, Michael D. ; Wikesjö, Ulf M E ; Hall, Jan. / Bone-implant contact at calcium phosphate-coated and porous titanium oxide (TiUnite™)-modified oral implants. In: Clinical Oral Implants Research. 2005 ; Vol. 16, No. 5. pp. 532-539.
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abstract = "Background: Calcium phosphate (CP)-coated implants are usually referred to as having osteoconductive properties, whereas titanium implants with a native oxide layer are considered less osteoconductive. Often smooth titanium oxides (TOs) are compared to relatively rough CP structures. The objective of this study was to evaluate osteoconduction by comparing bone-implant contact at a relatively smooth, highly crystalline CP coating with a structured, porous TO (TiUnite™)-modified surface. Material and methods: Ten adult Hound Labrador mongrel dogs were used. Four titanium implants (Nobel Biocare) with CP-coated (2) or TO-modified (2) surfaces were installed 12 weeks following mandibular premolar and molar teeth extraction. The implants were alternated within and between jaw quadrants in consecutive animals. Mucosal flaps were advanced and sutured leaving the implants in a submerged position. The animals were injected with fluorescent bone labels at 3 and 4 weeks postsurgery, and pre-euthanasia to monitor progress of bone formation. The animals were euthanized at 8 weeks postsurgery and block biopsies were prepared for histologic and histometric analysis. Results: There were no remarkable differences in bone formation and apparent bone-implant contact comparing the TO-modified and CP-coated surfaces. However, the measured average bone-implant contact was 71{\%} and 57{\%} (P=0.027) for TO-modified and CP-coated implants, respectively. Conclusions: We conclude that the TO surface exhibits osteoconductive properties exceeding that of the CP surface. One or several of the chemical and physical properties of the TO surface may result in the remarkable bone formation along its surface. This study indicated that crystallinity and/or chemistry may be important.",
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AU - Xiropaidis, Andreas V.

AU - Qahash, Mohammed

AU - Lim, Won Hee

AU - Shanaman, Richard H.

AU - Rohrer, Michael D.

AU - Wikesjö, Ulf M E

AU - Hall, Jan

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N2 - Background: Calcium phosphate (CP)-coated implants are usually referred to as having osteoconductive properties, whereas titanium implants with a native oxide layer are considered less osteoconductive. Often smooth titanium oxides (TOs) are compared to relatively rough CP structures. The objective of this study was to evaluate osteoconduction by comparing bone-implant contact at a relatively smooth, highly crystalline CP coating with a structured, porous TO (TiUnite™)-modified surface. Material and methods: Ten adult Hound Labrador mongrel dogs were used. Four titanium implants (Nobel Biocare) with CP-coated (2) or TO-modified (2) surfaces were installed 12 weeks following mandibular premolar and molar teeth extraction. The implants were alternated within and between jaw quadrants in consecutive animals. Mucosal flaps were advanced and sutured leaving the implants in a submerged position. The animals were injected with fluorescent bone labels at 3 and 4 weeks postsurgery, and pre-euthanasia to monitor progress of bone formation. The animals were euthanized at 8 weeks postsurgery and block biopsies were prepared for histologic and histometric analysis. Results: There were no remarkable differences in bone formation and apparent bone-implant contact comparing the TO-modified and CP-coated surfaces. However, the measured average bone-implant contact was 71% and 57% (P=0.027) for TO-modified and CP-coated implants, respectively. Conclusions: We conclude that the TO surface exhibits osteoconductive properties exceeding that of the CP surface. One or several of the chemical and physical properties of the TO surface may result in the remarkable bone formation along its surface. This study indicated that crystallinity and/or chemistry may be important.

AB - Background: Calcium phosphate (CP)-coated implants are usually referred to as having osteoconductive properties, whereas titanium implants with a native oxide layer are considered less osteoconductive. Often smooth titanium oxides (TOs) are compared to relatively rough CP structures. The objective of this study was to evaluate osteoconduction by comparing bone-implant contact at a relatively smooth, highly crystalline CP coating with a structured, porous TO (TiUnite™)-modified surface. Material and methods: Ten adult Hound Labrador mongrel dogs were used. Four titanium implants (Nobel Biocare) with CP-coated (2) or TO-modified (2) surfaces were installed 12 weeks following mandibular premolar and molar teeth extraction. The implants were alternated within and between jaw quadrants in consecutive animals. Mucosal flaps were advanced and sutured leaving the implants in a submerged position. The animals were injected with fluorescent bone labels at 3 and 4 weeks postsurgery, and pre-euthanasia to monitor progress of bone formation. The animals were euthanized at 8 weeks postsurgery and block biopsies were prepared for histologic and histometric analysis. Results: There were no remarkable differences in bone formation and apparent bone-implant contact comparing the TO-modified and CP-coated surfaces. However, the measured average bone-implant contact was 71% and 57% (P=0.027) for TO-modified and CP-coated implants, respectively. Conclusions: We conclude that the TO surface exhibits osteoconductive properties exceeding that of the CP surface. One or several of the chemical and physical properties of the TO surface may result in the remarkable bone formation along its surface. This study indicated that crystallinity and/or chemistry may be important.

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KW - Dogs

KW - Implant surfaces

KW - Osseointegration

KW - Titanium

KW - Titanium oxide

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