Abstract
Background: Calcium phosphate (CP)-coated implants are usually referred to as having osteoconductive properties, whereas titanium implants with a native oxide layer are considered less osteoconductive. Often smooth titanium oxides (TOs) are compared to relatively rough CP structures. The objective of this study was to evaluate osteoconduction by comparing bone-implant contact at a relatively smooth, highly crystalline CP coating with a structured, porous TO (TiUnite™)-modified surface. Material and methods: Ten adult Hound Labrador mongrel dogs were used. Four titanium implants (Nobel Biocare) with CP-coated (2) or TO-modified (2) surfaces were installed 12 weeks following mandibular premolar and molar teeth extraction. The implants were alternated within and between jaw quadrants in consecutive animals. Mucosal flaps were advanced and sutured leaving the implants in a submerged position. The animals were injected with fluorescent bone labels at 3 and 4 weeks postsurgery, and pre-euthanasia to monitor progress of bone formation. The animals were euthanized at 8 weeks postsurgery and block biopsies were prepared for histologic and histometric analysis. Results: There were no remarkable differences in bone formation and apparent bone-implant contact comparing the TO-modified and CP-coated surfaces. However, the measured average bone-implant contact was 71% and 57% (P=0.027) for TO-modified and CP-coated implants, respectively. Conclusions: We conclude that the TO surface exhibits osteoconductive properties exceeding that of the CP surface. One or several of the chemical and physical properties of the TO surface may result in the remarkable bone formation along its surface. This study indicated that crystallinity and/or chemistry may be important.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 532-539 |
| Number of pages | 8 |
| Journal | Clinical Oral Implants Research |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1 2005 |
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Keywords
- Bone healing
- Calcium phosphate
- Dogs
- Implant surfaces
- Osseointegration
- Titanium
- Titanium oxide
ASJC Scopus subject areas
- Dentistry(all)
Cite this
Bone-implant contact at calcium phosphate-coated and porous titanium oxide (TiUnite™)-modified oral implants. / Xiropaidis, Andreas V.; Qahash, Mohammed; Lim, Won Hee; Shanaman, Richard H.; Rohrer, Michael D.; Wikesjö, Ulf M E; Hall, Jan.
In: Clinical Oral Implants Research, Vol. 16, No. 5, 01.10.2005, p. 532-539.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone-implant contact at calcium phosphate-coated and porous titanium oxide (TiUnite™)-modified oral implants
AU - Xiropaidis, Andreas V.
AU - Qahash, Mohammed
AU - Lim, Won Hee
AU - Shanaman, Richard H.
AU - Rohrer, Michael D.
AU - Wikesjö, Ulf M E
AU - Hall, Jan
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Background: Calcium phosphate (CP)-coated implants are usually referred to as having osteoconductive properties, whereas titanium implants with a native oxide layer are considered less osteoconductive. Often smooth titanium oxides (TOs) are compared to relatively rough CP structures. The objective of this study was to evaluate osteoconduction by comparing bone-implant contact at a relatively smooth, highly crystalline CP coating with a structured, porous TO (TiUnite™)-modified surface. Material and methods: Ten adult Hound Labrador mongrel dogs were used. Four titanium implants (Nobel Biocare) with CP-coated (2) or TO-modified (2) surfaces were installed 12 weeks following mandibular premolar and molar teeth extraction. The implants were alternated within and between jaw quadrants in consecutive animals. Mucosal flaps were advanced and sutured leaving the implants in a submerged position. The animals were injected with fluorescent bone labels at 3 and 4 weeks postsurgery, and pre-euthanasia to monitor progress of bone formation. The animals were euthanized at 8 weeks postsurgery and block biopsies were prepared for histologic and histometric analysis. Results: There were no remarkable differences in bone formation and apparent bone-implant contact comparing the TO-modified and CP-coated surfaces. However, the measured average bone-implant contact was 71% and 57% (P=0.027) for TO-modified and CP-coated implants, respectively. Conclusions: We conclude that the TO surface exhibits osteoconductive properties exceeding that of the CP surface. One or several of the chemical and physical properties of the TO surface may result in the remarkable bone formation along its surface. This study indicated that crystallinity and/or chemistry may be important.
AB - Background: Calcium phosphate (CP)-coated implants are usually referred to as having osteoconductive properties, whereas titanium implants with a native oxide layer are considered less osteoconductive. Often smooth titanium oxides (TOs) are compared to relatively rough CP structures. The objective of this study was to evaluate osteoconduction by comparing bone-implant contact at a relatively smooth, highly crystalline CP coating with a structured, porous TO (TiUnite™)-modified surface. Material and methods: Ten adult Hound Labrador mongrel dogs were used. Four titanium implants (Nobel Biocare) with CP-coated (2) or TO-modified (2) surfaces were installed 12 weeks following mandibular premolar and molar teeth extraction. The implants were alternated within and between jaw quadrants in consecutive animals. Mucosal flaps were advanced and sutured leaving the implants in a submerged position. The animals were injected with fluorescent bone labels at 3 and 4 weeks postsurgery, and pre-euthanasia to monitor progress of bone formation. The animals were euthanized at 8 weeks postsurgery and block biopsies were prepared for histologic and histometric analysis. Results: There were no remarkable differences in bone formation and apparent bone-implant contact comparing the TO-modified and CP-coated surfaces. However, the measured average bone-implant contact was 71% and 57% (P=0.027) for TO-modified and CP-coated implants, respectively. Conclusions: We conclude that the TO surface exhibits osteoconductive properties exceeding that of the CP surface. One or several of the chemical and physical properties of the TO surface may result in the remarkable bone formation along its surface. This study indicated that crystallinity and/or chemistry may be important.
KW - Bone healing
KW - Calcium phosphate
KW - Dogs
KW - Implant surfaces
KW - Osseointegration
KW - Titanium
KW - Titanium oxide
UR - http://www.scopus.com/inward/record.url?scp=27744551307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744551307&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0501.2005.01126.x
DO - 10.1111/j.1600-0501.2005.01126.x
M3 - Article
VL - 16
SP - 532
EP - 539
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
SN - 0905-7161
IS - 5
ER -