Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry

Christopher R. Cogle, Neil D. Theise, Dong Tao Fu, Deniz Ucar, Sean Lee, Steven M. Guthrie, Jean Lonergan, Witold Rybka, Diane S. Krause, Edward W. Scott

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Bone marrow cells have the capacity to contribute to distant organs. We show that marrow also contributes to epithelial neoplasias of the small bowel, colon, and lung, but not the skin. In particular, epithelial neoplasias found in patients after hematopoietic cell transplantations demonstrate that human marrow incorporates into neoplasias by adopting the phenotype of the surrounding neoplastic environment. To more rigorously evaluate marrow contribution to epithelial cancer, we employed mouse models of intestinal and lung neoplasias, which revealed specifically that the hematopoietic stem cell and its progeny incorporate within cancer. Furthermore, this marrow involvement in epithelial cancer does not appear to occur by induction of stable fusion. Whereas previous claims have been made that marrow can serve as a direct source of epithelial neoplasia, our results indicate a more cautionary note, that marrow contributes to cancer as a means of developmental mimicry.

Original languageEnglish (US)
Pages (from-to)1881-1887
Number of pages7
JournalStem Cells
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2007

Fingerprint

Bone Marrow
Neoplasms
Lung
Cell Transplantation
Hematopoietic Stem Cells
Bone Marrow Cells
Colon
Phenotype
Skin

Keywords

  • Bone marrow cells
  • Bone marrow transplantation
  • Differentiation
  • Hematopoietic stem cell
  • Malignancy
  • Plasticity

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

Cite this

Cogle, C. R., Theise, N. D., Fu, D. T., Ucar, D., Lee, S., Guthrie, S. M., ... Scott, E. W. (2007). Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry. Stem Cells, 25(8), 1881-1887. https://doi.org/10.1634/stemcells.2007-0163

Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry. / Cogle, Christopher R.; Theise, Neil D.; Fu, Dong Tao; Ucar, Deniz; Lee, Sean; Guthrie, Steven M.; Lonergan, Jean; Rybka, Witold; Krause, Diane S.; Scott, Edward W.

In: Stem Cells, Vol. 25, No. 8, 01.08.2007, p. 1881-1887.

Research output: Contribution to journalArticle

Cogle, CR, Theise, ND, Fu, DT, Ucar, D, Lee, S, Guthrie, SM, Lonergan, J, Rybka, W, Krause, DS & Scott, EW 2007, 'Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry', Stem Cells, vol. 25, no. 8, pp. 1881-1887. https://doi.org/10.1634/stemcells.2007-0163
Cogle, Christopher R. ; Theise, Neil D. ; Fu, Dong Tao ; Ucar, Deniz ; Lee, Sean ; Guthrie, Steven M. ; Lonergan, Jean ; Rybka, Witold ; Krause, Diane S. ; Scott, Edward W. / Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry. In: Stem Cells. 2007 ; Vol. 25, No. 8. pp. 1881-1887.
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