Brain-derived neurotrophic factor: Findings in schizophrenia

Peter F Buckley, Anilkumar R Pillai, Kristy R. Howell

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Purpose of Review: To review the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity related to schizophrenia and the recent findings that have been reported on the status of BDNF in patients with schizophrenia and its association with the clinical measures. Recent Findings: Peripheral BDNF levels have been found altered in first-episode patients with psychosis and also in chronic schizophrenia patients. A few studies have reported changes in peripheral BDNF levels following antipsychotic treatment. The role of Val66Met polymorphism in BDNF has been shown to play an important role in structural and functional plasticity in schizophrenia. Summary: Although peripheral BDNF levels hold promise for providing new perspectives for the development of novel therapeutic strategies for the treatment of schizophrenia, additional studies including efforts to prove its potential as a biomarker are warranted.

Original languageEnglish (US)
Pages (from-to)122-127
Number of pages6
JournalCurrent Opinion in Psychiatry
Volume24
Issue number2
DOIs
StatePublished - Mar 1 2011

Fingerprint

Brain-Derived Neurotrophic Factor
Schizophrenia
Neuronal Plasticity
Psychotic Disorders
Antipsychotic Agents
Therapeutics
Biomarkers

Keywords

  • Val66Met
  • antipsychotic
  • brain-derived neurotrophic factor
  • neuroplasticity
  • peripheral
  • psychosis
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Brain-derived neurotrophic factor : Findings in schizophrenia. / Buckley, Peter F; Pillai, Anilkumar R; Howell, Kristy R.

In: Current Opinion in Psychiatry, Vol. 24, No. 2, 01.03.2011, p. 122-127.

Research output: Contribution to journalArticle

Buckley, Peter F ; Pillai, Anilkumar R ; Howell, Kristy R. / Brain-derived neurotrophic factor : Findings in schizophrenia. In: Current Opinion in Psychiatry. 2011 ; Vol. 24, No. 2. pp. 122-127.
@article{2a4296f0a30a41fdbe219e4d4c6fe01e,
title = "Brain-derived neurotrophic factor: Findings in schizophrenia",
abstract = "Purpose of Review: To review the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity related to schizophrenia and the recent findings that have been reported on the status of BDNF in patients with schizophrenia and its association with the clinical measures. Recent Findings: Peripheral BDNF levels have been found altered in first-episode patients with psychosis and also in chronic schizophrenia patients. A few studies have reported changes in peripheral BDNF levels following antipsychotic treatment. The role of Val66Met polymorphism in BDNF has been shown to play an important role in structural and functional plasticity in schizophrenia. Summary: Although peripheral BDNF levels hold promise for providing new perspectives for the development of novel therapeutic strategies for the treatment of schizophrenia, additional studies including efforts to prove its potential as a biomarker are warranted.",
keywords = "Val66Met, antipsychotic, brain-derived neurotrophic factor, neuroplasticity, peripheral, psychosis, schizophrenia",
author = "Buckley, {Peter F} and Pillai, {Anilkumar R} and Howell, {Kristy R.}",
year = "2011",
month = "3",
day = "1",
doi = "10.1097/YCO.0b013e3283436eb7",
language = "English (US)",
volume = "24",
pages = "122--127",
journal = "Current Opinion in Psychiatry",
issn = "0951-7367",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Brain-derived neurotrophic factor

T2 - Findings in schizophrenia

AU - Buckley, Peter F

AU - Pillai, Anilkumar R

AU - Howell, Kristy R.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Purpose of Review: To review the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity related to schizophrenia and the recent findings that have been reported on the status of BDNF in patients with schizophrenia and its association with the clinical measures. Recent Findings: Peripheral BDNF levels have been found altered in first-episode patients with psychosis and also in chronic schizophrenia patients. A few studies have reported changes in peripheral BDNF levels following antipsychotic treatment. The role of Val66Met polymorphism in BDNF has been shown to play an important role in structural and functional plasticity in schizophrenia. Summary: Although peripheral BDNF levels hold promise for providing new perspectives for the development of novel therapeutic strategies for the treatment of schizophrenia, additional studies including efforts to prove its potential as a biomarker are warranted.

AB - Purpose of Review: To review the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity related to schizophrenia and the recent findings that have been reported on the status of BDNF in patients with schizophrenia and its association with the clinical measures. Recent Findings: Peripheral BDNF levels have been found altered in first-episode patients with psychosis and also in chronic schizophrenia patients. A few studies have reported changes in peripheral BDNF levels following antipsychotic treatment. The role of Val66Met polymorphism in BDNF has been shown to play an important role in structural and functional plasticity in schizophrenia. Summary: Although peripheral BDNF levels hold promise for providing new perspectives for the development of novel therapeutic strategies for the treatment of schizophrenia, additional studies including efforts to prove its potential as a biomarker are warranted.

KW - Val66Met

KW - antipsychotic

KW - brain-derived neurotrophic factor

KW - neuroplasticity

KW - peripheral

KW - psychosis

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=79951581460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951581460&partnerID=8YFLogxK

U2 - 10.1097/YCO.0b013e3283436eb7

DO - 10.1097/YCO.0b013e3283436eb7

M3 - Article

C2 - 21248641

AN - SCOPUS:79951581460

VL - 24

SP - 122

EP - 127

JO - Current Opinion in Psychiatry

JF - Current Opinion in Psychiatry

SN - 0951-7367

IS - 2

ER -