Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats

P. C. Huttemeier, Edmond F Ritter, H. Benveniste

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Circulating calcitonin gene-related peptide (CGRP) concentrations are elevated in experimental and clinical sepsis. CGRP causes hypotension and tachycardia, suggesting that the peptide might mediate the acute circulatory changes in sepsis. To test this hypothesis we administered Escherichia coli endotoxin (8 mg/kg iv) to Nembutal- (pentobarbital sodium; 50 mg/kg) anesthetized rats. Endotoxin caused hypotension and tachycardia within 60 min that stabilized for 90 min. After 2 h more severe hypotension developed, and 80% of rats died spontaneously after 3 h. In other endotoxic rats we administered 20 nmol of the CGRP receptor antagonist hCGRP(8-37) intravenously at 60 min. hCGRP(8-37) transiently reversed tachycardia (from 469 ± 11 to 407 ± 7 beats/min, P < 0.05) and increased mean blood pressure (from 63 ± 4 to 93 ± 11 mmHg, P < 0.05) over 30 min, after which hemodynamics and survival rates were no different from untreated animals. The results suggest that CGRP plays an important role in the acute circulatory changes of endotoxemia. More detailed work is necessary to determine the effects of CGRP antagonism on cardiac function, regional blood flow, and overall survival rates in sepsis.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume265
Issue number2 34-2
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Calcitonin Gene-Related Peptide
Tachycardia
Hypotension
Sepsis
Pentobarbital
Calcitonin Gene-Related Peptide Receptors
Endotoxemia
Regional Blood Flow
Endotoxins
Hemodynamics
Blood Pressure
Peptides
calcitonin gene-related peptide (8-37)

Keywords

  • effects of calcitonin gene-related peptide receptor antagonists
  • endotoxic shock
  • improved hemodynamics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats. / Huttemeier, P. C.; Ritter, Edmond F; Benveniste, H.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 265, No. 2 34-2, 01.01.1993.

Research output: Contribution to journalArticle

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