Abstract
Background: The study's objective was to investigate the risks of developing cardiac disorders following the administration of chemotherapy and radiation therapy in patients with non-small-cell lung cancer (NSCLC). Methods: The study consisted of 34 209 patients aged ≥65 years with American Joint Committee on Cancer stages I-IV NSCLC identified from the Surveillance, Epidemiology, and End Result-Medicare linked database (1991-2002) who were free of cardiac disorders at NSCLC diagnosis. Results: There were significant associations between the use of chemotherapy/radiation and the risks of developing ischemic heart disease, conduction disorders, cardiac dysfunction, and heart failure. The absolute risks for cardiac dysfunction increased with the administration of chemotherapy-only and radiation-only, and incrementally with chemoradiation. Men, blacks, older patients, those with higher comorbidity scores, and advanced disease were at higher risk. The risk for ischemic heart disease increased when radiation/chemoradiation were rendered to the left lung and both lungs and for cardiac dysfunction, radiation administered to the left lung. Conclusions: There were significant associations especially for cardiac dysfunction with use of chemotherapy/radiation therapy and risks of developing cardiac toxicity in NSCLC patients. The risks of treatment-associated cardiac toxicity, specifically ischemic heart disease and cardiac dysfunction, were greatest among those with left-sided lung tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1825-1833 |
| Number of pages | 9 |
| Journal | Annals of Oncology |
| Volume | 21 |
| Issue number | 9 |
| DOIs | |
| State | Published - Mar 8 2010 |
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Keywords
- Cardiac disorders
- Chemotherapy
- Lung cancer
- Radiation therapy
- Toxicit
ASJC Scopus subject areas
- Oncology
- Hematology
Cite this
Cardiac toxicity in association with chemotherapy and radiation therapy in a large cohort of older patients with non-small-cell lung cancer. / Hardy, Dale Sharon; Liu, C. C.; Cormier, J. N.; Xia, R.; Du, X. L.
In: Annals of Oncology, Vol. 21, No. 9, 08.03.2010, p. 1825-1833.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiac toxicity in association with chemotherapy and radiation therapy in a large cohort of older patients with non-small-cell lung cancer
AU - Hardy, Dale Sharon
AU - Liu, C. C.
AU - Cormier, J. N.
AU - Xia, R.
AU - Du, X. L.
PY - 2010/3/8
Y1 - 2010/3/8
N2 - Background: The study's objective was to investigate the risks of developing cardiac disorders following the administration of chemotherapy and radiation therapy in patients with non-small-cell lung cancer (NSCLC). Methods: The study consisted of 34 209 patients aged ≥65 years with American Joint Committee on Cancer stages I-IV NSCLC identified from the Surveillance, Epidemiology, and End Result-Medicare linked database (1991-2002) who were free of cardiac disorders at NSCLC diagnosis. Results: There were significant associations between the use of chemotherapy/radiation and the risks of developing ischemic heart disease, conduction disorders, cardiac dysfunction, and heart failure. The absolute risks for cardiac dysfunction increased with the administration of chemotherapy-only and radiation-only, and incrementally with chemoradiation. Men, blacks, older patients, those with higher comorbidity scores, and advanced disease were at higher risk. The risk for ischemic heart disease increased when radiation/chemoradiation were rendered to the left lung and both lungs and for cardiac dysfunction, radiation administered to the left lung. Conclusions: There were significant associations especially for cardiac dysfunction with use of chemotherapy/radiation therapy and risks of developing cardiac toxicity in NSCLC patients. The risks of treatment-associated cardiac toxicity, specifically ischemic heart disease and cardiac dysfunction, were greatest among those with left-sided lung tumors.
AB - Background: The study's objective was to investigate the risks of developing cardiac disorders following the administration of chemotherapy and radiation therapy in patients with non-small-cell lung cancer (NSCLC). Methods: The study consisted of 34 209 patients aged ≥65 years with American Joint Committee on Cancer stages I-IV NSCLC identified from the Surveillance, Epidemiology, and End Result-Medicare linked database (1991-2002) who were free of cardiac disorders at NSCLC diagnosis. Results: There were significant associations between the use of chemotherapy/radiation and the risks of developing ischemic heart disease, conduction disorders, cardiac dysfunction, and heart failure. The absolute risks for cardiac dysfunction increased with the administration of chemotherapy-only and radiation-only, and incrementally with chemoradiation. Men, blacks, older patients, those with higher comorbidity scores, and advanced disease were at higher risk. The risk for ischemic heart disease increased when radiation/chemoradiation were rendered to the left lung and both lungs and for cardiac dysfunction, radiation administered to the left lung. Conclusions: There were significant associations especially for cardiac dysfunction with use of chemotherapy/radiation therapy and risks of developing cardiac toxicity in NSCLC patients. The risks of treatment-associated cardiac toxicity, specifically ischemic heart disease and cardiac dysfunction, were greatest among those with left-sided lung tumors.
KW - Cardiac disorders
KW - Chemotherapy
KW - Lung cancer
KW - Radiation therapy
KW - Toxicit
UR - http://www.scopus.com/inward/record.url?scp=77956118807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956118807&partnerID=8YFLogxK
U2 - 10.1093/annonc/mdq042
DO - 10.1093/annonc/mdq042
M3 - Article
C2 - 20211871
AN - SCOPUS:77956118807
VL - 21
SP - 1825
EP - 1833
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - 9
ER -