Cardiovascular Characteristics in American Youth With Prehypertension

Haidong Zhu, Weili Yan, Dongliang Ge, Frank A. Treiber, Gregory A Harshfield, Kakota Gaston Kapuku, Harold Snieder, Yanbin Dong

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background: Cardiovascular structure and function in youth with prehypertension have been incompletely investigated. Methods: Casual and ambulatory blood pressure (BP) measurement, arterial stiffness, noninvasive hemodynamic profiles, and cardiac structure were studied in a twin cohort of American black and white youth (n = 942; mean age, 17.6 ± 3.3 years SD). A family history of essential hypertension was used as a proxy to study genetic susceptibility to prehypertension. Results: The occurrence of prehypertension was approximately 12% in the entire sample. Body mass index and waist circumference were significantly greater in prehypertensive subjects than in normotensive subjects. The 24-h ambulatory systolic BP (SBP), 24-h ambulatory diastolic BP (DBP), nighttime ambulatory SBP, and nighttime ambulatory DBP were significantly elevated in prehypertensive subjects compared with normotensive subjects. In whites, prehypertensive subjects compared with normotensive subjects showed increased radial (6.8 ± 0.1 v 6.2 ± 0.1 m/sec, P < .001) and foot pulse-wave velocity (PWV) (7.4 ± 0.1 v 7.0 ± 0.1 m/sec, P = .001). In whites, the total peripheral resistance index was greater in prehypertensive subjects than in normotensive subjects (P = .005). White prehypertensive subjects had a significantly greater heart rate than white normotensive subjects (69.0 ± 1.4 v 64.0 ± 0.6 bpm). In contrast, in blacks, the cardiac index was higher in prehypertensive subjects than in normotensive subjects (3.3 ± 0.1 v 3.0 ± 0.1 L/min/m2, P = .004). In blacks and whites, there were no statistical differences in the parameters of left-ventricular structure between normotensive subjects and prehypertensive subjects. Finally, prehypertensive subjects were more likely to have a positive family history of essential hypertension, especially in blacks. Conclusions: Prehypertension compared with normotension exhibited unfavorable cardiovascular phenotypes. Cardiovascular characteristics of prehypertension appear to be race-dependent.

Original languageEnglish (US)
Pages (from-to)1051-1057
Number of pages7
JournalAmerican journal of hypertension
Volume20
Issue number10
DOIs
StatePublished - Oct 1 2007

Fingerprint

Prehypertension
Blood Pressure
Pulse Wave Analysis
Vascular Stiffness
Waist Circumference
Proxy
Genetic Predisposition to Disease
Vascular Resistance
Foot
Body Mass Index
Heart Rate
Hemodynamics
Phenotype

Keywords

  • Prehypertension
  • ambulatory blood pressure
  • arterial stiffness
  • hemodynamics
  • left-ventricular structure and function
  • youth

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Cardiovascular Characteristics in American Youth With Prehypertension. / Zhu, Haidong; Yan, Weili; Ge, Dongliang; Treiber, Frank A.; Harshfield, Gregory A; Kapuku, Kakota Gaston; Snieder, Harold; Dong, Yanbin.

In: American journal of hypertension, Vol. 20, No. 10, 01.10.2007, p. 1051-1057.

Research output: Contribution to journalArticle

@article{b929866e9b354e7aa70e724749e77b52,
title = "Cardiovascular Characteristics in American Youth With Prehypertension",
abstract = "Background: Cardiovascular structure and function in youth with prehypertension have been incompletely investigated. Methods: Casual and ambulatory blood pressure (BP) measurement, arterial stiffness, noninvasive hemodynamic profiles, and cardiac structure were studied in a twin cohort of American black and white youth (n = 942; mean age, 17.6 ± 3.3 years SD). A family history of essential hypertension was used as a proxy to study genetic susceptibility to prehypertension. Results: The occurrence of prehypertension was approximately 12{\%} in the entire sample. Body mass index and waist circumference were significantly greater in prehypertensive subjects than in normotensive subjects. The 24-h ambulatory systolic BP (SBP), 24-h ambulatory diastolic BP (DBP), nighttime ambulatory SBP, and nighttime ambulatory DBP were significantly elevated in prehypertensive subjects compared with normotensive subjects. In whites, prehypertensive subjects compared with normotensive subjects showed increased radial (6.8 ± 0.1 v 6.2 ± 0.1 m/sec, P < .001) and foot pulse-wave velocity (PWV) (7.4 ± 0.1 v 7.0 ± 0.1 m/sec, P = .001). In whites, the total peripheral resistance index was greater in prehypertensive subjects than in normotensive subjects (P = .005). White prehypertensive subjects had a significantly greater heart rate than white normotensive subjects (69.0 ± 1.4 v 64.0 ± 0.6 bpm). In contrast, in blacks, the cardiac index was higher in prehypertensive subjects than in normotensive subjects (3.3 ± 0.1 v 3.0 ± 0.1 L/min/m2, P = .004). In blacks and whites, there were no statistical differences in the parameters of left-ventricular structure between normotensive subjects and prehypertensive subjects. Finally, prehypertensive subjects were more likely to have a positive family history of essential hypertension, especially in blacks. Conclusions: Prehypertension compared with normotension exhibited unfavorable cardiovascular phenotypes. Cardiovascular characteristics of prehypertension appear to be race-dependent.",
keywords = "Prehypertension, ambulatory blood pressure, arterial stiffness, hemodynamics, left-ventricular structure and function, youth",
author = "Haidong Zhu and Weili Yan and Dongliang Ge and Treiber, {Frank A.} and Harshfield, {Gregory A} and Kapuku, {Kakota Gaston} and Harold Snieder and Yanbin Dong",
year = "2007",
month = "10",
day = "1",
doi = "10.1016/j.amjhyper.2007.05.009",
language = "English (US)",
volume = "20",
pages = "1051--1057",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Cardiovascular Characteristics in American Youth With Prehypertension

AU - Zhu, Haidong

AU - Yan, Weili

AU - Ge, Dongliang

AU - Treiber, Frank A.

AU - Harshfield, Gregory A

AU - Kapuku, Kakota Gaston

AU - Snieder, Harold

AU - Dong, Yanbin

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Background: Cardiovascular structure and function in youth with prehypertension have been incompletely investigated. Methods: Casual and ambulatory blood pressure (BP) measurement, arterial stiffness, noninvasive hemodynamic profiles, and cardiac structure were studied in a twin cohort of American black and white youth (n = 942; mean age, 17.6 ± 3.3 years SD). A family history of essential hypertension was used as a proxy to study genetic susceptibility to prehypertension. Results: The occurrence of prehypertension was approximately 12% in the entire sample. Body mass index and waist circumference were significantly greater in prehypertensive subjects than in normotensive subjects. The 24-h ambulatory systolic BP (SBP), 24-h ambulatory diastolic BP (DBP), nighttime ambulatory SBP, and nighttime ambulatory DBP were significantly elevated in prehypertensive subjects compared with normotensive subjects. In whites, prehypertensive subjects compared with normotensive subjects showed increased radial (6.8 ± 0.1 v 6.2 ± 0.1 m/sec, P < .001) and foot pulse-wave velocity (PWV) (7.4 ± 0.1 v 7.0 ± 0.1 m/sec, P = .001). In whites, the total peripheral resistance index was greater in prehypertensive subjects than in normotensive subjects (P = .005). White prehypertensive subjects had a significantly greater heart rate than white normotensive subjects (69.0 ± 1.4 v 64.0 ± 0.6 bpm). In contrast, in blacks, the cardiac index was higher in prehypertensive subjects than in normotensive subjects (3.3 ± 0.1 v 3.0 ± 0.1 L/min/m2, P = .004). In blacks and whites, there were no statistical differences in the parameters of left-ventricular structure between normotensive subjects and prehypertensive subjects. Finally, prehypertensive subjects were more likely to have a positive family history of essential hypertension, especially in blacks. Conclusions: Prehypertension compared with normotension exhibited unfavorable cardiovascular phenotypes. Cardiovascular characteristics of prehypertension appear to be race-dependent.

AB - Background: Cardiovascular structure and function in youth with prehypertension have been incompletely investigated. Methods: Casual and ambulatory blood pressure (BP) measurement, arterial stiffness, noninvasive hemodynamic profiles, and cardiac structure were studied in a twin cohort of American black and white youth (n = 942; mean age, 17.6 ± 3.3 years SD). A family history of essential hypertension was used as a proxy to study genetic susceptibility to prehypertension. Results: The occurrence of prehypertension was approximately 12% in the entire sample. Body mass index and waist circumference were significantly greater in prehypertensive subjects than in normotensive subjects. The 24-h ambulatory systolic BP (SBP), 24-h ambulatory diastolic BP (DBP), nighttime ambulatory SBP, and nighttime ambulatory DBP were significantly elevated in prehypertensive subjects compared with normotensive subjects. In whites, prehypertensive subjects compared with normotensive subjects showed increased radial (6.8 ± 0.1 v 6.2 ± 0.1 m/sec, P < .001) and foot pulse-wave velocity (PWV) (7.4 ± 0.1 v 7.0 ± 0.1 m/sec, P = .001). In whites, the total peripheral resistance index was greater in prehypertensive subjects than in normotensive subjects (P = .005). White prehypertensive subjects had a significantly greater heart rate than white normotensive subjects (69.0 ± 1.4 v 64.0 ± 0.6 bpm). In contrast, in blacks, the cardiac index was higher in prehypertensive subjects than in normotensive subjects (3.3 ± 0.1 v 3.0 ± 0.1 L/min/m2, P = .004). In blacks and whites, there were no statistical differences in the parameters of left-ventricular structure between normotensive subjects and prehypertensive subjects. Finally, prehypertensive subjects were more likely to have a positive family history of essential hypertension, especially in blacks. Conclusions: Prehypertension compared with normotension exhibited unfavorable cardiovascular phenotypes. Cardiovascular characteristics of prehypertension appear to be race-dependent.

KW - Prehypertension

KW - ambulatory blood pressure

KW - arterial stiffness

KW - hemodynamics

KW - left-ventricular structure and function

KW - youth

UR - http://www.scopus.com/inward/record.url?scp=34548817019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548817019&partnerID=8YFLogxK

U2 - 10.1016/j.amjhyper.2007.05.009

DO - 10.1016/j.amjhyper.2007.05.009

M3 - Article

C2 - 17903687

AN - SCOPUS:34548817019

VL - 20

SP - 1051

EP - 1057

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 10

ER -