Carnitine status in renal dialysis patients

D. F. Lapp, T. Abnev, A. L. Carter', A. G. Wassersten, Laura L Mulloy, J. Boudreaux, J. Jenninos

Research output: Contribution to journalArticle

Abstract

Using a radioenzymatic assay, the plasma concentrations of acetyl (AC), free (FC), and total (TC) carnitine were measured in three groups of 20 subjects: group 1. long tern hemodialysis patients receiving IV carnitine for at least 6 months; group 2. long term hemodialysis patients; group 3. non-dialyzed subjects. Group AC FC TC AC/acylC nmol/ml nmol/ml nmol/ml % (SD) (SD) (SD) (SD) 1.116.6(76.4) 216.7(92.8) 383.2(164.3) 66.2(13.6) 2. 6.3(2.2) 24.4(12.3) 40.2(15.6) 36.4(7.6) 3. 7.0(3.2) 36.7(10.2) 47.8(13.1) 62.8(8.4) These data indicate that carnitine treatment results in an increase total plasma carnitine. The acyl/free carnitine ratio increases in dialysis subject. In contrast, the AC/acylc ratio decreased however carnitine treatment return this ratio to that found in the controls.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996
Externally publishedYes

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Dialysis
Carnitine
Renal Dialysis
Charadriiformes
Plasmas
Assays
Therapeutics

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Lapp, D. F., Abnev, T., Carter', A. L., Wassersten, A. G., Mulloy, L. L., Boudreaux, J., & Jenninos, J. (1996). Carnitine status in renal dialysis patients. FASEB Journal, 10(3).

Carnitine status in renal dialysis patients. / Lapp, D. F.; Abnev, T.; Carter', A. L.; Wassersten, A. G.; Mulloy, Laura L; Boudreaux, J.; Jenninos, J.

In: FASEB Journal, Vol. 10, No. 3, 01.12.1996.

Research output: Contribution to journalArticle

Lapp, DF, Abnev, T, Carter', AL, Wassersten, AG, Mulloy, LL, Boudreaux, J & Jenninos, J 1996, 'Carnitine status in renal dialysis patients', FASEB Journal, vol. 10, no. 3.
Lapp DF, Abnev T, Carter' AL, Wassersten AG, Mulloy LL, Boudreaux J et al. Carnitine status in renal dialysis patients. FASEB Journal. 1996 Dec 1;10(3).
Lapp, D. F. ; Abnev, T. ; Carter', A. L. ; Wassersten, A. G. ; Mulloy, Laura L ; Boudreaux, J. ; Jenninos, J. / Carnitine status in renal dialysis patients. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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