Central nervous system controls of adipose tissue apoptosis

Mary Anne Della-Fera, Mark W Hamrick, Clifton A. Baile

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Background Increased adipose tissue mass is a common denominator in both obesity and osteoporosis. Obesity is characterized by increased fat storage in subcutaneous and visceral adipose depots resulting from an imbalance between energy intake and energy expenditure, whereas osteoporosis is associated with increased adipocyte production in bone marrow and is not necessarily associated with increased overall adiposity. In obesity a reduction of adipose tissue mass is accompanied by amelioration of the pathophysiological effects. There are currently no therapies that specifically reduce bone marrow adipocyte populations. However, bone formation decreases with increasing proportion of marrow adipocytes (Verma et al., 2002); thus, it is likely that reversal or prevention of bone marrow adiposity may improve bone quality. In the USA, the prevalence of overweight among adults increased by 61% from 1991 to 2000; currently, more than half of all adults are considered overweight and approximately 20% are extremely overweight or obese (Flegal et al., 1998). Obesity is not just a cosmetic problem – there is much evidence indicating that higher levels of body fat are associated with an increased risk for the development of numerous adverse health consequences (Visscher & Seidell, 2001). There is also a tremendous economic burden associated with the recent rise in prevalence of obesity. The economic costs of obesity are estimated to be ∼7% of total healthcare costs in the USA (Colditz, 1999).

Original languageEnglish (US)
Title of host publicationNeurobiology of Obesity
PublisherCambridge University Press
Pages285-301
Number of pages17
ISBN (Electronic)9780511541643
ISBN (Print)9780521860338
DOIs
StatePublished - Jan 1 2008

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Adipose Tissue
Central Nervous System
Obesity
Apoptosis
Bone Marrow
Adipocytes
Adiposity
Osteoporosis
Economics
Energy Intake
Osteogenesis
Cosmetics
Health Care Costs
Energy Metabolism
Fats
Costs and Cost Analysis
Bone and Bones
Health
Population
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Della-Fera, M. A., Hamrick, M. W., & Baile, C. A. (2008). Central nervous system controls of adipose tissue apoptosis. In Neurobiology of Obesity (pp. 285-301). Cambridge University Press. https://doi.org/10.1017/CBO9780511541643.011

Central nervous system controls of adipose tissue apoptosis. / Della-Fera, Mary Anne; Hamrick, Mark W; Baile, Clifton A.

Neurobiology of Obesity. Cambridge University Press, 2008. p. 285-301.

Research output: Chapter in Book/Report/Conference proceedingChapter

Della-Fera, MA, Hamrick, MW & Baile, CA 2008, Central nervous system controls of adipose tissue apoptosis. in Neurobiology of Obesity. Cambridge University Press, pp. 285-301. https://doi.org/10.1017/CBO9780511541643.011
Della-Fera MA, Hamrick MW, Baile CA. Central nervous system controls of adipose tissue apoptosis. In Neurobiology of Obesity. Cambridge University Press. 2008. p. 285-301 https://doi.org/10.1017/CBO9780511541643.011
Della-Fera, Mary Anne ; Hamrick, Mark W ; Baile, Clifton A. / Central nervous system controls of adipose tissue apoptosis. Neurobiology of Obesity. Cambridge University Press, 2008. pp. 285-301
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