Ceramide signaling in cancer and stem cells

Erhard Bieberich

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Most of the previous work on the sphingolipid ceramide has been devoted to its function as an apoptosis inducer. Recent studies, however, have shown that in stem cells, ceramide has additional nonapoptotic functions. In this article, ceramide signaling will be reviewed in light of 'systems interface biology': as an interconnection of sphingolipid metabolism, membrane biophysics and cell signaling. The focus will be on the metabolic interconversion of ceramide and sphingomyelin or sphingosine-1-phosphate. Lipid rafts and sphingolipid-induced protein scaffolds will be discussed as a membrane interface for lipid-controlled cell signaling. Ceramide/sphingomyelin and ceramide/ sphingosine-1-phosphate-interdependent cell-signaling pathways are significant for the regulation of cell polarity, apoptosis and/or proliferation, and as novel pharmacologic targets in cancer and stem cells.

Original languageEnglish (US)
Pages (from-to)273-300
Number of pages28
JournalFuture Lipidology
Volume3
Issue number3
DOIs
StatePublished - Jun 1 2008

Fingerprint

Neoplastic Stem Cells
Ceramides
Stem cells
Sphingolipids
Cell signaling
Sphingomyelins
Apoptosis
Biophysics
Cell Polarity
Systems Biology
Membranes
Lipids
Membrane Lipids
Metabolism
Scaffolds
Stem Cells
Cell Proliferation
Cell Membrane
Cells
Proteins

Keywords

  • Apoptosis
  • Cancer
  • Cell polarity
  • Ceramide
  • ES cells
  • Lipid rafts
  • Sphingomyelin
  • Sphingosine-1-phosphate

ASJC Scopus subject areas

  • Biochemistry

Cite this

Ceramide signaling in cancer and stem cells. / Bieberich, Erhard.

In: Future Lipidology, Vol. 3, No. 3, 01.06.2008, p. 273-300.

Research output: Contribution to journalReview article

Bieberich, Erhard. / Ceramide signaling in cancer and stem cells. In: Future Lipidology. 2008 ; Vol. 3, No. 3. pp. 273-300.
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