Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy

Cole A. Giller, Gary Bowman, Hunter Dyer, Lee Mootz, William Krippner

Research output: Contribution to journalArticle

533 Citations (Scopus)

Abstract

FORTY-FIVE MEASUREMENTS of diameters of 12 human cerebral arteries were performed during 10 craniotomies under moderate changes in mean blood pressure and end tidal CO2. The mean change in blood pressure was 30 ± 16 mm Hg (standard deviation) and that of end tidal CO2 was 14 ± 6 mm Hg (standard deviation). These changes were induced with nitroprusside, phenylephrine, and adjustment of ventilator rate. Measurements were made through the operating microscope focused at the highest power, with meticulous attention to constant angle and distance from the artery. The mean diameter change in the large cerebral arteries (carotid, middle cerebral artery, vertebral artery) was less than 4%, but the smaller arteries (anterior cerebral artery, M2 segment of middle cerebral artery) showed diameter changes as large as 29% and 21% to end tidal CO2 and blood pressure changes, respectively. These data suggest that at the time of craniotomy, diameters of the large cerebral vessels do not significantly change during moderate variations in blood pressure and CO2, but that larger changes may occur in smaller vessels. This constancy of diameter suggests that the transcranial Doppler velocities obtained during intraoperative monitoring of craniotomies may closely reflect blood flow through the insonated artery.

Original languageEnglish (US)
Pages (from-to)737-742
Number of pages6
JournalNeurosurgery
Volume32
Issue number5
DOIs
StatePublished - May 1993

Fingerprint

Craniotomy
Carbon Dioxide
Blood Pressure
Cerebral Arteries
Arteries
Middle Cerebral Artery
Intraoperative Monitoring
Anterior Cerebral Artery
Vertebral Artery
Nitroprusside
Phenylephrine
Mechanical Ventilators

Keywords

  • Cerebral autoregulation
  • Cerebral blood flow
  • Transcranial doppler

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. / Giller, Cole A.; Bowman, Gary; Dyer, Hunter; Mootz, Lee; Krippner, William.

In: Neurosurgery, Vol. 32, No. 5, 05.1993, p. 737-742.

Research output: Contribution to journalArticle

Giller, Cole A. ; Bowman, Gary ; Dyer, Hunter ; Mootz, Lee ; Krippner, William. / Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. In: Neurosurgery. 1993 ; Vol. 32, No. 5. pp. 737-742.
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