Cerebral infarction in sickle cell anemia

Mechanism based on CT and MRI

R. J. Adams, Fenwick T Nichols, V. McKie, K. McKie, P. Milner, T. E. Gammal

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

We studied 25 patients with sickle cell anemia and cerebral infarction. We classified lesions as to probable mechanism (large versus small vessel disease) based on the CT/MRI appearance of established infarction. Most patients had CT/ MRI patterns of major cerebral vessel occlusion (41%) or borderzone (distal insufficiency) infarcts (31%) best explained by large cerebral vessel vasculopathy. Seven of 25 (28%) had either isolated subcortical (12%) or small cortical branch occlusion (16%) consistent with other mechanisms such as small vessel occlusion or embolism. These results suggest that most clinically recognized cerebral infarctions in sickle cell anemia are caused by large vessel disease, but this mechanism may not account for symptoms of cerebral ischemia in all cases.

Original languageEnglish (US)
Pages (from-to)1012-1017
Number of pages6
JournalNeurology
Volume38
Issue number7
StatePublished - Jan 1 1988

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Cerebral Infarction
Sickle Cell Anemia
Embolism
Brain Ischemia
Infarction

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Adams, R. J., Nichols, F. T., McKie, V., McKie, K., Milner, P., & Gammal, T. E. (1988). Cerebral infarction in sickle cell anemia: Mechanism based on CT and MRI. Neurology, 38(7), 1012-1017.

Cerebral infarction in sickle cell anemia : Mechanism based on CT and MRI. / Adams, R. J.; Nichols, Fenwick T; McKie, V.; McKie, K.; Milner, P.; Gammal, T. E.

In: Neurology, Vol. 38, No. 7, 01.01.1988, p. 1012-1017.

Research output: Contribution to journalArticle

Adams, RJ, Nichols, FT, McKie, V, McKie, K, Milner, P & Gammal, TE 1988, 'Cerebral infarction in sickle cell anemia: Mechanism based on CT and MRI', Neurology, vol. 38, no. 7, pp. 1012-1017.
Adams RJ, Nichols FT, McKie V, McKie K, Milner P, Gammal TE. Cerebral infarction in sickle cell anemia: Mechanism based on CT and MRI. Neurology. 1988 Jan 1;38(7):1012-1017.
Adams, R. J. ; Nichols, Fenwick T ; McKie, V. ; McKie, K. ; Milner, P. ; Gammal, T. E. / Cerebral infarction in sickle cell anemia : Mechanism based on CT and MRI. In: Neurology. 1988 ; Vol. 38, No. 7. pp. 1012-1017.
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