Abstract
We studied 25 patients with sickle cell anemia and cerebral infarction. We classified lesions as to probable mechanism (large versus small vessel disease) based on the CT/MRI appearance of established infarction. Most patients had CT/ MRI patterns of major cerebral vessel occlusion (41%) or borderzone (distal insufficiency) infarcts (31%) best explained by large cerebral vessel vasculopathy. Seven of 25 (28%) had either isolated subcortical (12%) or small cortical branch occlusion (16%) consistent with other mechanisms such as small vessel occlusion or embolism. These results suggest that most clinically recognized cerebral infarctions in sickle cell anemia are caused by large vessel disease, but this mechanism may not account for symptoms of cerebral ischemia in all cases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1012-1017 |
| Number of pages | 6 |
| Journal | Neurology |
| Volume | 38 |
| Issue number | 7 |
| State | Published - Jul 1988 |
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ASJC Scopus subject areas
- Clinical Neurology
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Cerebral infarction in sickle cell anemia : Mechanism based on CT and MRI. / Adams, R. J.; Nichols, F. T.; McKie, V.; McKie, K.; Milner, P.; Gammal, T. E.
In: Neurology, Vol. 38, No. 7, 07.1988, p. 1012-1017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral infarction in sickle cell anemia
T2 - Mechanism based on CT and MRI
AU - Adams, R. J.
AU - Nichols, F. T.
AU - McKie, V.
AU - McKie, K.
AU - Milner, P.
AU - Gammal, T. E.
PY - 1988/7
Y1 - 1988/7
N2 - We studied 25 patients with sickle cell anemia and cerebral infarction. We classified lesions as to probable mechanism (large versus small vessel disease) based on the CT/MRI appearance of established infarction. Most patients had CT/ MRI patterns of major cerebral vessel occlusion (41%) or borderzone (distal insufficiency) infarcts (31%) best explained by large cerebral vessel vasculopathy. Seven of 25 (28%) had either isolated subcortical (12%) or small cortical branch occlusion (16%) consistent with other mechanisms such as small vessel occlusion or embolism. These results suggest that most clinically recognized cerebral infarctions in sickle cell anemia are caused by large vessel disease, but this mechanism may not account for symptoms of cerebral ischemia in all cases.
AB - We studied 25 patients with sickle cell anemia and cerebral infarction. We classified lesions as to probable mechanism (large versus small vessel disease) based on the CT/MRI appearance of established infarction. Most patients had CT/ MRI patterns of major cerebral vessel occlusion (41%) or borderzone (distal insufficiency) infarcts (31%) best explained by large cerebral vessel vasculopathy. Seven of 25 (28%) had either isolated subcortical (12%) or small cortical branch occlusion (16%) consistent with other mechanisms such as small vessel occlusion or embolism. These results suggest that most clinically recognized cerebral infarctions in sickle cell anemia are caused by large vessel disease, but this mechanism may not account for symptoms of cerebral ischemia in all cases.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023730856&partnerID=8YFLogxK
M3 - Article
C2 - 3386816
AN - SCOPUS:0023730856
VL - 38
SP - 1012
EP - 1017
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 7
ER -