Certain norditerpenoid alkaloids and their cardiovascular action

Haridutt K. Desai, Bradley P. Hart, Robert William Caldwell, Jianzhong-Huang, S. William Pelletier

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Thirteen new derivatives of norditerpenoid alkaloids, namely, 8- deacetyl-8-p-aminobenzoyldelphinine (1), 8-deacetyl-8-anthranoyldelphinine (2), 8-deacetyl-8-(4-hydroxy-3-methoxycinnamoyl)delphinine (3), 16- demethoxy-15,16-didehydro-8-p-anisoyl-14-benzoyldelphonine (4), 6- acetylheteratisine N-oxide (6), 3,8-diacetylfalconerine (7), 8- stearoylfalconerine (8), 8-linolenylfalconerine (9), 13-acetylpyrodelphinine (11), 13-acetyldelphinine N-oxide (13), N-deacetyl 8,9-diacetyllappaconitine (14), 8,9-(methylenedioxy)lappaconine (15), and 16-epipyroaconitine N-oxide (17), were prepared, and their structures were established by analysis of spectroscopic data (1D and 2D NMR, HRFABMS). The preliminary in vivo cardiovascular action (hypotensive, bradycardic, and ventricular arrhythmias) of these new compounds was tested in male Sprague-Dawley rats. The results are reported herein.

Original languageEnglish (US)
Pages (from-to)743-748
Number of pages6
JournalJournal of Natural Products
Volume61
Issue number6
DOIs
StatePublished - Jun 1 1998

Fingerprint

diterpenoid alkaloids
Diterpenes
Alkaloids
Oxides
oxides
arrhythmia
Sprague Dawley Rats
Rats
Cardiac Arrhythmias
data analysis
Nuclear magnetic resonance
Derivatives
rats

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Certain norditerpenoid alkaloids and their cardiovascular action. / Desai, Haridutt K.; Hart, Bradley P.; Caldwell, Robert William; Jianzhong-Huang; Pelletier, S. William.

In: Journal of Natural Products, Vol. 61, No. 6, 01.06.1998, p. 743-748.

Research output: Contribution to journalArticle

Desai, HK, Hart, BP, Caldwell, RW, Jianzhong-Huang & Pelletier, SW 1998, 'Certain norditerpenoid alkaloids and their cardiovascular action', Journal of Natural Products, vol. 61, no. 6, pp. 743-748. https://doi.org/10.1021/np970499j
Desai, Haridutt K. ; Hart, Bradley P. ; Caldwell, Robert William ; Jianzhong-Huang ; Pelletier, S. William. / Certain norditerpenoid alkaloids and their cardiovascular action. In: Journal of Natural Products. 1998 ; Vol. 61, No. 6. pp. 743-748.
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