Certain norditerpenoid alkaloids and their cardiovascular action

Haridutt K. Desai, Bradley P. Hart, Robert William Caldwell, Jianzhong-Huang, S. William Pelletier

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Thirteen new derivatives of norditerpenoid alkaloids, namely, 8- deacetyl-8-p-aminobenzoyldelphinine (1), 8-deacetyl-8-anthranoyldelphinine (2), 8-deacetyl-8-(4-hydroxy-3-methoxycinnamoyl)delphinine (3), 16- demethoxy-15,16-didehydro-8-p-anisoyl-14-benzoyldelphonine (4), 6- acetylheteratisine N-oxide (6), 3,8-diacetylfalconerine (7), 8- stearoylfalconerine (8), 8-linolenylfalconerine (9), 13-acetylpyrodelphinine (11), 13-acetyldelphinine N-oxide (13), N-deacetyl 8,9-diacetyllappaconitine (14), 8,9-(methylenedioxy)lappaconine (15), and 16-epipyroaconitine N-oxide (17), were prepared, and their structures were established by analysis of spectroscopic data (1D and 2D NMR, HRFABMS). The preliminary in vivo cardiovascular action (hypotensive, bradycardic, and ventricular arrhythmias) of these new compounds was tested in male Sprague-Dawley rats. The results are reported herein.

Original languageEnglish (US)
Pages (from-to)743-748
Number of pages6
JournalJournal of Natural Products
Volume61
Issue number6
DOIs
StatePublished - Jun 1 1998

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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