Changes in BiP (GRP78) levels upon HSV-1 infection are strain dependent

Hanwen Mao, Diana Palmer, Kenneth S. Rosenthal

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

BiP (grp78) is a chaperone protein which can also regulate the unfolded protein response of the cell. Levels of BiP increased in cells infected by the small plaque producing, cell associated, neuroinvasive strains of HSV-1 (SP7, 490) but decreased in cells infected with KOS, a large plaque, attenuated strain. BiP protein synthesis continued early in infection and BiP was sequestered and its degradation was limited during SP7 infection. BiP protein synthesis stopped and the protein was degraded in KOS infected cells. These viral strain dependent differences in BiP concentration may influence other aspects of the viral interaction with the target cell and its host.

Original languageEnglish (US)
Pages (from-to)127-135
Number of pages9
JournalVirus Research
Volume76
Issue number2
DOIs
StatePublished - Jun 23 2001
Externally publishedYes

Keywords

  • BiP
  • ER stress
  • HSV
  • Strain dependence

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

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