Characteristics of inflammation common to both diabetes and periodontitis: Are predictive diagnosis and targeted preventive measures possible?

Philip Jerry Hanes, Ranjitha Krishna

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Diabetes and periodontitis are chronic inflammatory disorders that contribute to each others' severity and worsen each others' prognosis. Studies have shown that patients with diabetes are at increased risk of developing periodontitis, and that diabetics with untreated periodontitis have more difficulty controlling serum glucose. Periodontal treatment that reduces gingival inflammation aids in the control of hyperglycemia. Periodontitis is accompanied by gingival bleeding and the production of an inflammatory exudate termed gingival crevicular fluid (GCF) that arises from the inflamed gingival tissues surrounding the teeth. GCF contains byproducts of connective tissue degradation, enzymes from host and bacterial cells, cytokines and other inflammatory mediators, and has been studied for screening blood glucose and for biomarkers of both diabetes and periodontitis. This review focuses on the inter-relationship between diabetes and periodontitis and the biomarkers common to both these diseases that may enable earlier detection, targeted preventive measures and individualized therapeutic intervention of these chronic conditions.

Original languageEnglish (US)
Pages (from-to)101-116
Number of pages16
JournalEPMA Journal
Volume1
Issue number1
DOIs
StatePublished - Mar 1 2010

Fingerprint

Periodontitis
Medical problems
Inflammation
Gingival Crevicular Fluid
Biomarkers
Tissue
Fluids
Chronic Periodontitis
Byproducts
Blood Glucose
Exudates and Transudates
Screening
Hyperglycemia
Connective Tissue
Cytokines
Tooth
Glucose
Degradation
Hemorrhage
Enzymes

Keywords

  • Biomarkers
  • Diabetes
  • Gingival crevicular fluid
  • Individualized treatment
  • Inflammation
  • Periodontitis

ASJC Scopus subject areas

  • Drug Discovery
  • Health Policy
  • Biochemistry, medical

Cite this

Characteristics of inflammation common to both diabetes and periodontitis : Are predictive diagnosis and targeted preventive measures possible? / Hanes, Philip Jerry; Krishna, Ranjitha.

In: EPMA Journal, Vol. 1, No. 1, 01.03.2010, p. 101-116.

Research output: Contribution to journalReview article

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