Characterization of gangliosides by direct inlet chemical ionization mass spectrometry

T. Argia, Robert K Yu, T. Miyatake

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Permethylated derivatives of N-acetylneuraminic acid-containing G(M3), N-glycolylneuraminic acid-containing G(M3), G(D1a), and G(D1b), were analyzed by direct inlet ammonia chemical ionization (CI) mass spectrometry. These compounds were found to yield simple fragmentations, prominent fragment ions in the high mass region, and characteristic fragment ions corresponding to the cleavage of glycosidic linkages. This method also provides detailed information on the carbohydrate sequence and lipophilic composition in gangliosides.

Original languageEnglish (US)
Pages (from-to)1096-1101
Number of pages6
JournalJournal of Lipid Research
Volume25
Issue number10
StatePublished - Dec 1 1984

Fingerprint

Gangliosides
Ionization
Mass spectrometry
Mass Spectrometry
Carbohydrate Sequence
Ions
N-Acetylneuraminic Acid
Ammonia
Carbohydrates
Derivatives
Chemical analysis
N-glycolylneuraminic acid

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

Cite this

Characterization of gangliosides by direct inlet chemical ionization mass spectrometry. / Argia, T.; Yu, Robert K; Miyatake, T.

In: Journal of Lipid Research, Vol. 25, No. 10, 01.12.1984, p. 1096-1101.

Research output: Contribution to journalArticle

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