Chemokines, chemokine receptors and the gastrointestinal system

Hiroshi Miyazaki, Kazuaki Takabe, W. Andrew Yeudall

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

The biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors, which include epidermal growth factor receptor agonists and members of the transforming growth factor β family. Furthermore, the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches. In this review, we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)2847-2863
Number of pages17
JournalWorld Journal of Gastroenterology
Volume19
Issue number19
DOIs
StatePublished - May 21 2013

Keywords

  • Cancer
  • Chemokine
  • Digestive system
  • Receptor
  • Signal transduction
  • Targeted therapeutics
  • Tumor progression

ASJC Scopus subject areas

  • Gastroenterology

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