The effects of scopolamine (anticholinergic) and methysergide (antiserotonergic) on memory and long-latency auditory cognitive evoked potentials (EPs) were tested in 16 normal adults. Recent memory was impaired by both drugs. In contrast, scopolamine, but not methysergide, significantly delayed P3 latency and decreased P3 amplitude. Immediate memory and the earlier EP components (i.e., N1 and P2) were unaffected. The findings support the hypothesis that cholinergic neurons are important in the neuronal networks generating the P3 potential. Serotonergic neurons do not appear to play a major role in the networks that generate the P3.
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society|
|State||Published - Mar 1989|
ASJC Scopus subject areas
- Clinical Psychology
- Clinical Neurology