Cholinergic and serotonergic effects on the P3 potential and recent memory.

K. J. Meador, D. W. Loring, H. C. Davis, Kapil Dev Sethi, B. R. Patel, R. J. Adams, E. J. Hammond

Research output: Contribution to journalArticle

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Abstract

The effects of scopolamine (anticholinergic) and methysergide (antiserotonergic) on memory and long-latency auditory cognitive evoked potentials (EPs) were tested in 16 normal adults. Recent memory was impaired by both drugs. In contrast, scopolamine, but not methysergide, significantly delayed P3 latency and decreased P3 amplitude. Immediate memory and the earlier EP components (i.e., N1 and P2) were unaffected. The findings support the hypothesis that cholinergic neurons are important in the neuronal networks generating the P3 potential. Serotonergic neurons do not appear to play a major role in the networks that generate the P3.

Original languageEnglish (US)
Pages (from-to)252-260
Number of pages9
JournalJournal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society
Volume11
Issue number2
DOIs
StatePublished - Jan 1 1989

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Methysergide
Scopolamine Hydrobromide
Cholinergic Agents
Serotonergic Neurons
Auditory Evoked Potentials
Cholinergic Neurons
Cholinergic Antagonists
Short-Term Memory
Evoked Potentials
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

Cite this

Cholinergic and serotonergic effects on the P3 potential and recent memory. / Meador, K. J.; Loring, D. W.; Davis, H. C.; Sethi, Kapil Dev; Patel, B. R.; Adams, R. J.; Hammond, E. J.

In: Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society, Vol. 11, No. 2, 01.01.1989, p. 252-260.

Research output: Contribution to journalArticle

Meador, K. J. ; Loring, D. W. ; Davis, H. C. ; Sethi, Kapil Dev ; Patel, B. R. ; Adams, R. J. ; Hammond, E. J. / Cholinergic and serotonergic effects on the P3 potential and recent memory. In: Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. 1989 ; Vol. 11, No. 2. pp. 252-260.
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