Cholinergic and serotonergic effects on the P3 potential and recent memory.

K. J. Meador, D. W. Loring, H. C. Davis, Kapil Dev Sethi, B. R. Patel, R. J. Adams, E. J. Hammond

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


The effects of scopolamine (anticholinergic) and methysergide (antiserotonergic) on memory and long-latency auditory cognitive evoked potentials (EPs) were tested in 16 normal adults. Recent memory was impaired by both drugs. In contrast, scopolamine, but not methysergide, significantly delayed P3 latency and decreased P3 amplitude. Immediate memory and the earlier EP components (i.e., N1 and P2) were unaffected. The findings support the hypothesis that cholinergic neurons are important in the neuronal networks generating the P3 potential. Serotonergic neurons do not appear to play a major role in the networks that generate the P3.

Original languageEnglish (US)
Pages (from-to)252-260
Number of pages9
JournalJournal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society
Issue number2
StatePublished - Mar 1989

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology


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