Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1

Sonia A. Rasmussen, Jennifer Overman, Susanne A.M. Thomson, Steven D. Colman, Corinne R. Abernathy, Rachael E. Trimpert, Rebecca Moose, Gurinder Virdi, Kyle Roux, Mislen Bauer, Amyn Mohammed Rojiani, Bernard L. Maria, David Muir, Margaret R. Wallace

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Abstract

Neurofibromatosis type 1 (NF1) is a common autosomal dominant condition characterized by benign tumor (neurofibroma) growth and increased risk of malignancy. Dermal neurofibromas, arising from superficial nerves, are primarily of cosmetic significance, whereas plexiform neurofibromas, typically larger and associated with deeply placed nerves, extend into contiguous tissues and may cause serious functional impairment. Malignant peripheral nerve sheath tumors (MPNSTs) seem to arise from plexiform neurofibromas. The NF1 gene, on chromosome segment 17q11.2, encodes a protein that has tumor suppressor function. Loss of heterozygosity (LOH) for NF1 has been reported in some neurofibromas and NF1 malignancies, but plexiform tumors have been poorly represented. Also, the studies did not always employ the same markers, preventing simple comparison of the frequency and extent of LOH among different tumor types. Our chromosome 17 LOH analysis in a cohort of three tumor types was positive for NF1 allele loss in 2/15 (13%) dermal neurofibromas, 4/10 (40%) plexiform neurofibromas, and 3/5 (60%) MPNSTs. Although the region of loss varied, the p arm (including TP53) was lost only in malignant tumors. The losses in the plexiform tumors all included sequences distal to NF1. No subtle TP53 mutations were found in any tumors. This study also reports the identification of both NF1 'hits' in plexiform tumors, further supporting the tumor suppressor role of the NF1 gene in this tumor type. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)425-431
Number of pages7
JournalGenes Chromosomes and Cancer
Volume28
Issue number4
DOIs
StatePublished - Aug 1 2000

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Chromosomes, Human, Pair 17
Neurofibromatosis 1
Loss of Heterozygosity
Neurofibroma
Neoplasms
Plexiform Neurofibroma
Neurofibromatosis 1 Genes
Neurilemmoma
Tumor Suppressor Proteins
Skin
Cosmetics
Chromosomes
Alleles

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Rasmussen, S. A., Overman, J., Thomson, S. A. M., Colman, S. D., Abernathy, C. R., Trimpert, R. E., ... Wallace, M. R. (2000). Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1. Genes Chromosomes and Cancer, 28(4), 425-431. https://doi.org/10.1002/1098-2264(200008)28:4<425::AID-GCC8>3.0.CO;2-E

Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1. / Rasmussen, Sonia A.; Overman, Jennifer; Thomson, Susanne A.M.; Colman, Steven D.; Abernathy, Corinne R.; Trimpert, Rachael E.; Moose, Rebecca; Virdi, Gurinder; Roux, Kyle; Bauer, Mislen; Rojiani, Amyn Mohammed; Maria, Bernard L.; Muir, David; Wallace, Margaret R.

In: Genes Chromosomes and Cancer, Vol. 28, No. 4, 01.08.2000, p. 425-431.

Research output: Contribution to journalArticle

Rasmussen, SA, Overman, J, Thomson, SAM, Colman, SD, Abernathy, CR, Trimpert, RE, Moose, R, Virdi, G, Roux, K, Bauer, M, Rojiani, AM, Maria, BL, Muir, D & Wallace, MR 2000, 'Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1', Genes Chromosomes and Cancer, vol. 28, no. 4, pp. 425-431. https://doi.org/10.1002/1098-2264(200008)28:4<425::AID-GCC8>3.0.CO;2-E
Rasmussen, Sonia A. ; Overman, Jennifer ; Thomson, Susanne A.M. ; Colman, Steven D. ; Abernathy, Corinne R. ; Trimpert, Rachael E. ; Moose, Rebecca ; Virdi, Gurinder ; Roux, Kyle ; Bauer, Mislen ; Rojiani, Amyn Mohammed ; Maria, Bernard L. ; Muir, David ; Wallace, Margaret R. / Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1. In: Genes Chromosomes and Cancer. 2000 ; Vol. 28, No. 4. pp. 425-431.
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abstract = "Neurofibromatosis type 1 (NF1) is a common autosomal dominant condition characterized by benign tumor (neurofibroma) growth and increased risk of malignancy. Dermal neurofibromas, arising from superficial nerves, are primarily of cosmetic significance, whereas plexiform neurofibromas, typically larger and associated with deeply placed nerves, extend into contiguous tissues and may cause serious functional impairment. Malignant peripheral nerve sheath tumors (MPNSTs) seem to arise from plexiform neurofibromas. The NF1 gene, on chromosome segment 17q11.2, encodes a protein that has tumor suppressor function. Loss of heterozygosity (LOH) for NF1 has been reported in some neurofibromas and NF1 malignancies, but plexiform tumors have been poorly represented. Also, the studies did not always employ the same markers, preventing simple comparison of the frequency and extent of LOH among different tumor types. Our chromosome 17 LOH analysis in a cohort of three tumor types was positive for NF1 allele loss in 2/15 (13{\%}) dermal neurofibromas, 4/10 (40{\%}) plexiform neurofibromas, and 3/5 (60{\%}) MPNSTs. Although the region of loss varied, the p arm (including TP53) was lost only in malignant tumors. The losses in the plexiform tumors all included sequences distal to NF1. No subtle TP53 mutations were found in any tumors. This study also reports the identification of both NF1 'hits' in plexiform tumors, further supporting the tumor suppressor role of the NF1 gene in this tumor type. (C) 2000 Wiley-Liss, Inc.",
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AU - Rasmussen, Sonia A.

AU - Overman, Jennifer

AU - Thomson, Susanne A.M.

AU - Colman, Steven D.

AU - Abernathy, Corinne R.

AU - Trimpert, Rachael E.

AU - Moose, Rebecca

AU - Virdi, Gurinder

AU - Roux, Kyle

AU - Bauer, Mislen

AU - Rojiani, Amyn Mohammed

AU - Maria, Bernard L.

AU - Muir, David

AU - Wallace, Margaret R.

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N2 - Neurofibromatosis type 1 (NF1) is a common autosomal dominant condition characterized by benign tumor (neurofibroma) growth and increased risk of malignancy. Dermal neurofibromas, arising from superficial nerves, are primarily of cosmetic significance, whereas plexiform neurofibromas, typically larger and associated with deeply placed nerves, extend into contiguous tissues and may cause serious functional impairment. Malignant peripheral nerve sheath tumors (MPNSTs) seem to arise from plexiform neurofibromas. The NF1 gene, on chromosome segment 17q11.2, encodes a protein that has tumor suppressor function. Loss of heterozygosity (LOH) for NF1 has been reported in some neurofibromas and NF1 malignancies, but plexiform tumors have been poorly represented. Also, the studies did not always employ the same markers, preventing simple comparison of the frequency and extent of LOH among different tumor types. Our chromosome 17 LOH analysis in a cohort of three tumor types was positive for NF1 allele loss in 2/15 (13%) dermal neurofibromas, 4/10 (40%) plexiform neurofibromas, and 3/5 (60%) MPNSTs. Although the region of loss varied, the p arm (including TP53) was lost only in malignant tumors. The losses in the plexiform tumors all included sequences distal to NF1. No subtle TP53 mutations were found in any tumors. This study also reports the identification of both NF1 'hits' in plexiform tumors, further supporting the tumor suppressor role of the NF1 gene in this tumor type. (C) 2000 Wiley-Liss, Inc.

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