Ciguatera

Andrew E.B. Swift, Thomas R. Swift

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Ciguatera is a type of marine food poisoning produced by the consumption of ciguatoxic reef fish. The disease is of significant concern in many tropical areas where it has been known for centuries. Although mortality from ciguatera is low, morbidity is high and symptoms may be debilitating and prolonged. Ciguatera produces characteristic gastrointestinal, neurological, and to a lesser extent, cardiovascular symptoms. Though the symptoms are relatively well documented, the disease often goes unreported or misdiagnosed. The toxins responsible for ciguatera are produced by marine dinoflagellates associated with coral reefs. The toxins are ingested by and accumulate in the fishes which when consumed by man ultimately cause ciguatera. Recent advances in toxin pharmacology have identified ciguatoxin as a sodium channel agonist and have begun to address other aspects of ciguatera on the molecular level. Treatment with mannitol relieves the symptoms; the precise mechanism or mechanisms of action have not been proven. Immunoassays are being developed for detecting even negligible amounts of toxins in suspect fish flesh.

Original languageEnglish (US)
Pages (from-to)1-29
Number of pages29
JournalClinical Toxicology
Volume31
Issue number1
DOIs
StatePublished - Jan 1 1993

Fingerprint

Ciguatera Poisoning
Fish
Reefs
Sodium Channel Agonists
Ciguatoxins
Fishes
Mannitol
Coral Reefs
Dinoflagellida
Foodborne Diseases
Diagnostic Errors
Immunoassay
Pharmacology
Morbidity
Mortality

Keywords

  • Ciguatoxin
  • Dinoflagellida
  • Fish venoms
  • Human
  • Mannitol
  • Marine toxins
  • Poisoning

ASJC Scopus subject areas

  • Toxicology

Cite this

Ciguatera. / Swift, Andrew E.B.; Swift, Thomas R.

In: Clinical Toxicology, Vol. 31, No. 1, 01.01.1993, p. 1-29.

Research output: Contribution to journalArticle

Swift, Andrew E.B. ; Swift, Thomas R. / Ciguatera. In: Clinical Toxicology. 1993 ; Vol. 31, No. 1. pp. 1-29.
@article{ded1f5b0087f45f48253a184ddabb33f,
title = "Ciguatera",
abstract = "Ciguatera is a type of marine food poisoning produced by the consumption of ciguatoxic reef fish. The disease is of significant concern in many tropical areas where it has been known for centuries. Although mortality from ciguatera is low, morbidity is high and symptoms may be debilitating and prolonged. Ciguatera produces characteristic gastrointestinal, neurological, and to a lesser extent, cardiovascular symptoms. Though the symptoms are relatively well documented, the disease often goes unreported or misdiagnosed. The toxins responsible for ciguatera are produced by marine dinoflagellates associated with coral reefs. The toxins are ingested by and accumulate in the fishes which when consumed by man ultimately cause ciguatera. Recent advances in toxin pharmacology have identified ciguatoxin as a sodium channel agonist and have begun to address other aspects of ciguatera on the molecular level. Treatment with mannitol relieves the symptoms; the precise mechanism or mechanisms of action have not been proven. Immunoassays are being developed for detecting even negligible amounts of toxins in suspect fish flesh.",
keywords = "Ciguatoxin, Dinoflagellida, Fish venoms, Human, Mannitol, Marine toxins, Poisoning",
author = "Swift, {Andrew E.B.} and Swift, {Thomas R.}",
year = "1993",
month = "1",
day = "1",
doi = "10.3109/15563659309000371",
language = "English (US)",
volume = "31",
pages = "1--29",
journal = "Clinical Toxicology",
issn = "1556-3650",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Ciguatera

AU - Swift, Andrew E.B.

AU - Swift, Thomas R.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Ciguatera is a type of marine food poisoning produced by the consumption of ciguatoxic reef fish. The disease is of significant concern in many tropical areas where it has been known for centuries. Although mortality from ciguatera is low, morbidity is high and symptoms may be debilitating and prolonged. Ciguatera produces characteristic gastrointestinal, neurological, and to a lesser extent, cardiovascular symptoms. Though the symptoms are relatively well documented, the disease often goes unreported or misdiagnosed. The toxins responsible for ciguatera are produced by marine dinoflagellates associated with coral reefs. The toxins are ingested by and accumulate in the fishes which when consumed by man ultimately cause ciguatera. Recent advances in toxin pharmacology have identified ciguatoxin as a sodium channel agonist and have begun to address other aspects of ciguatera on the molecular level. Treatment with mannitol relieves the symptoms; the precise mechanism or mechanisms of action have not been proven. Immunoassays are being developed for detecting even negligible amounts of toxins in suspect fish flesh.

AB - Ciguatera is a type of marine food poisoning produced by the consumption of ciguatoxic reef fish. The disease is of significant concern in many tropical areas where it has been known for centuries. Although mortality from ciguatera is low, morbidity is high and symptoms may be debilitating and prolonged. Ciguatera produces characteristic gastrointestinal, neurological, and to a lesser extent, cardiovascular symptoms. Though the symptoms are relatively well documented, the disease often goes unreported or misdiagnosed. The toxins responsible for ciguatera are produced by marine dinoflagellates associated with coral reefs. The toxins are ingested by and accumulate in the fishes which when consumed by man ultimately cause ciguatera. Recent advances in toxin pharmacology have identified ciguatoxin as a sodium channel agonist and have begun to address other aspects of ciguatera on the molecular level. Treatment with mannitol relieves the symptoms; the precise mechanism or mechanisms of action have not been proven. Immunoassays are being developed for detecting even negligible amounts of toxins in suspect fish flesh.

KW - Ciguatoxin

KW - Dinoflagellida

KW - Fish venoms

KW - Human

KW - Mannitol

KW - Marine toxins

KW - Poisoning

UR - http://www.scopus.com/inward/record.url?scp=0027463546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027463546&partnerID=8YFLogxK

U2 - 10.3109/15563659309000371

DO - 10.3109/15563659309000371

M3 - Article

C2 - 8433404

AN - SCOPUS:0027463546

VL - 31

SP - 1

EP - 29

JO - Clinical Toxicology

JF - Clinical Toxicology

SN - 1556-3650

IS - 1

ER -