Circulating micro-RNAs as diagnostic biomarkers for endometriosis: Privation and promise

Warren B. Nothnick, Ayman Al-Hendy, John R. Lue

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Endometriosis represents a major medical concern in women of reproductive age. One of the remaining major hurdles for successful treatment of endometriosis is the limitation of the process of timely disease diagnosis. A simple blood test for endometriosis-specific biomarkers would offer a more timely accurate diagnosis for the disease, thus allowing for earlier treatment intervention. Although there have been considerable efforts to identify such biomarkers, no clear choice for such noninvasive diagnostic tools has been identified. Micro-RNAs are small noncoding RNAs that have been evaluated intensively as biomarkers for several diseases, and they may hold promise for a diagnosis of endometriosis. In this review, we highlight the need for noninvasive testing for endometriosis, discuss the potential use of micro-RNAs as diagnostic tools for this disease, and consider potential limitations in the use of these small RNA molecules as diagnostic markers for endometriosis.

Original languageEnglish (US)
Pages (from-to)719-726
Number of pages8
JournalJournal of Minimally Invasive Gynecology
Volume22
Issue number5
DOIs
StatePublished - 2015

Keywords

  • Diagnostic biomarker
  • Endometriosis
  • MicroRNA

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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