Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

N. Pabla, Z. Dong

Research output: Contribution to journalReview article

990 Scopus citations

Abstract

Cisplatin is one of the most widely used and most potent chemotherapy drugs. However, side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the use of cisplatin and related platinum-based therapeutics. Recent research has shed significant new lights on the mechanism of cisplatin nephrotoxicity, especially on the signaling pathways leading to tubular cell death and inflammation. Renoprotective approaches are being discovered, but the protective effects are mostly partial, suggesting the need for combinatorial strategies. Importantly, it is unclear whether these approaches would limit the anticancer effects of cisplatin in tumors. Examination of tumor-bearing animals and identification of novel renoprotective strategies that do not diminish the anticancer efficacy of cisplatin are essential to the development of clinically applicable interventions.

Original languageEnglish (US)
Pages (from-to)994-1007
Number of pages14
JournalKidney International
Volume73
Issue number9
DOIs
StatePublished - May 2008

Keywords

  • Apoptosis
  • Cisplatin
  • Inflammation
  • Nephrotoxicity
  • Renoprotection

ASJC Scopus subject areas

  • Nephrology

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